STXBP2 Antibodies

AND STXBP2 ELISA kits, STXBP2 Proteins

Many biological assays use antibodies to detect STXBP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with STXBP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop STXBP2 antibodies...

We validate the specificity of these antibodies to STXBP2 by testing them on tissues known to express STXBP2 positively and negatively. Browse below to find the STXBP2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for STXBP2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the STXBP2 Western Blot Guide

STXBP2 Infographic by Boster Bio

All STXBP2 Products

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Applications

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Anti-STXBP2 Antibody Picoband®

IF analysis of STXBP2 using anti-STXBP2 antibody (PB9820)

Flow Cytometry analysis of U937 cells using anti-STXBP2 antibody (PB9820)

Western blot analysis of STXBP2 using anti-STXBP2 antibody (PB9820)

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # PB9820
100 μg/vial

STXBP2 Overview

Facts about Syntaxin-binding protein 2.

STXBP2 3D structure. Source: alphafold

Syntaxin-binding protein 2 (STXBP2)

Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion.

Regulates cytotoxic granule exocytosis in natural killer (NK) cells. .

Gene Information

Human
Gene Name:	STXBP2
Uniprot:	Q15833
Entrez:	6813

Family

Belongs to:

STXBP/unc-18/SEC1 family

Alternative Names

FHL5; Hunc18b; MUNC18-2; Protein unc-18 homolog 2; Protein unc-18 homolog B; STXBP2; syntaxin binding protein 2; syntaxin-binding protein 2; SyntaxinBP2; Syntaxin-BP2; Unc18-2; UNC18B; unc-18B; UNC18Bpp10122

Molecular Weight

Mass (kDA):
66.453 kDA

Genomic Context


Human

Location:	19p13.2
Sequence:	19; NC_000019.10 (7637110..7647873)

Tissue Specificity

Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.

Diseases

Lymphohistiocytosis, Hemophagocytic
Familial Hemophagocytic Lymphocytosis
Hemophagocytic Lymphohistiocytosis, Familial, 5
Virus Diseases
Immunologic Deficiency Syndromes
Inflammation
Infective Disorder
Hemorrhage
Primary Immune Deficiency Disorder
Lymphoma
Influenza
Epstein-barr Virus Infections

Hypogammaglobulinemia
Chediak-higashi Syndrome
X-linked Lymphoproliferative Disorders
Immune System Diseases
Lymphoproliferative Disorders
Malnutrition

Pathways

Transport
Exocytosis
Secretion
Vesicle Transport
Membrane Fusion
Localization
Immune Response
Synaptic Vesicle Exocytosis
Kidney Development
Cell Activation
Secretory Pathway
Intracellular Transport
Proton Transport

Cell Development
Insulin Secretion
Lymphocyte Homeostasis
Macrophage Activation
Cell Death
Cell Differentiation
Epithelial Cell Differentiation

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STXBP2

References

PMID: 8921365 by Ziegler S.F., et al. Molecular characterization of a nonneuronal human UNC18 homolog.

PMID: 19804848 by zur Stadt U., et al. Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11.