Supervillin Antibodies

AND SVIL ELISA kits, Supervillin Proteins

Many biological assays use antibodies to detect Supervillin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Supervillin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Supervillin antibodies...

We validate the specificity of these antibodies to Supervillin by testing them on tissues known to express SVIL positively and negatively. Browse below to find the SVIL antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SVIL Infographic by Boster Bio

All SVIL Products

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Product

Figures

Specificity

Applications

Price

Anti-Supervillin SVIL Antibody

Human, Mouse

ELISA, WB

$380
Cat # A05698
100ul

Supervillin (SVIL) (NM_003174) Human Over-expression Lysate

Human

$960
Cat # LS006840
20 µg, 100 µg

SVIL Overview

Facts about Supervillin.

SVIL 3D structure. Source: alphafold

Supervillin (SVIL)

Isoform 1: Types a high-affinity connection between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699).

Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration.

Gene Information

Human
Gene Name:	SVIL
Uniprot:	O95425
Entrez:	6840

Family

Belongs to:

villin/gelsolin family

Alternative Names

Archvillin; DKFZp686A17191; membrane-associated F-actin binding protein p205; p205/p250; Supervillin; SVIL

Molecular Weight

Mass (kDA):
247.746 kDA

Genomic Context


Human

Location:	10p11.23
Sequence:	10; NC_000010.11 (29457338..29736936, complement)

Tissue Specificity

Expressed in many tissues. Most abundant in muscle, bone marrow, thyroid gland and salivary gland. Isoform 1 (archvillin) is muscle specific.

Subcellular Localizations

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, invadopodium. Cell projection, podosome. Midbody. Cleavage furrow. Tightly associated with both actin filaments and plasma membranes.

Diseases

Malignant Neoplasms
Cell Invasion
Neoplasms
Tissue Adhesions
Prostatic Neoplasms
Malignant Neoplasm Of Lung
Carcinoma
Malignant Neoplasm Of Prostate
Adenocarcinoma
Cell Transformation, Neoplastic
Neoplasm Metastasis
Spinal And Bulbar Muscular Atrophy, X-linked 1

Periodontitis
Thrombus
Metastatic Malignant Neoplasm To The Lymph Node
Bone Neoplasms
Malignant Tumor Of Cervix
Immunologic Deficiency Syndromes
Androgenetic Alopecia

Interacting Proteins

Pathways

Cell Motility
Localization
Methylation
Cell Division
Cell Cycle
Protein Folding
Keratinocyte Proliferation
Endocytosis

Pathogenesis
Rna Interference
Cytokinesis

PTMs

Phosphorylation

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SVIL

References

PMID: 9867483 by Pope R.K., et al. Cloning, characterization, and chromosomal localization of human supervillin (SVIL).

PMID: 12711699 by Oh S.W., et al. Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton.