Plasminogen activator inhibitor 1 (SERPINE1)

Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774).

Is a main inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is needed for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461).