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- Table of Contents
SERPINE1 Antibodies
AND SERPINE1 ELISA kits, SERPINE1 Proteins
Many biological assays use antibodies to detect SERPINE1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SERPINE1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SERPINE1 antibodies...
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SERPINE1 Infographic by Boster Bio
All SERPINE1 Products
Product
Figures
Specificity
Applications
Price
Human PAI-1 ELISA Kit PicoKine®
10 Citations 7 Q&As
Human
ELISA
$499
Cat # EK0859
96 wells/kit, with removable strips.
Cat # EK0859
96 wells/kit, with removable strips.
Human
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M00637
100 μl
Cat # M00637
100 μl
Anti-PAI1/Serpine1 Antibody Picoband®
1 Citations 1 Q&As
Mouse, Rat
ELISA, WB
$370
Cat # A00637-2
100 μg/vial
Cat # A00637-2
100 μg/vial
Cynomolgus monkey, Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00637-1
100 μg
Cat # M00637-1
100 μg
SERPINE1 Overview
Facts about Plasminogen activator inhibitor 1.
Plasminogen activator inhibitor 1 (SERPINE1)
Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774).
Is a main inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is needed for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461).
Gene Information
| Human | |
|---|---|
| Gene Name: | SERPINE1 |
| Uniprot: | P05121 |
| Entrez: | 5054 |
Family
| Belongs to: |
|---|
| serpin family |
Alternative Names
Endothelial plasminogen activator inhibitor; Nexin; PAI1; PAI-1; PAI1PAI-1; PAISerpin E1; PLANH1; PLANH1plasminogen activator inhibitor 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 1; Serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1
Molecular Weight
Mass (kDA):
45.06 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.1 |
| Sequence: | 7; NC_000007.14 (101127104..101139247) |
Tissue Specificity
Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells.
Subcellular Localizations
Secreted.
Diseases
- Neoplasms
- Malignant Neoplasms
- Inflammation
- Thrombosis
- Cardiovascular Diseases
- Obesity
- Diabetes Mellitus
- Atherosclerosis
- Insulin Resistance
- Fibrosis
- Tissue Adhesions
- Cell Invasion
- Myocardial Infarction
Interacting Proteins
- ORM1
- SGTA
- SGTB
- UBQLN1
Pathways
- Fibrinolysis
- Coagulation
- Pathogenesis
- Secretion
- Hemostasis
- Cell Migration
- Angiogenesis
- Cell Adhesion
- Plasminogen Activation
- Cell Proliferation
- Proteolysis
- Inflammatory Response
- Blood Coagulation
PTMs
- Phosphorylation
- Cleavage
- Reduction
- Glycosylation
- Methylation
- Ribosylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERPINE1
bosterbio.com/bosterbio-gene-info-cards/SERPINE1
References
PMID: 2430793 by Pannekoek H., et al. Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.
PMID: 2820474 by Loskutoff D.J., et al. Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns.
20 Publications of Boster SERPINE1 Antibodies & ELISA Kits
- PubMed ID: 10.5935/abc.20190159, Evaluation of Serum Levels of Inflammation, Fibrinolysis and Oxidative Stress Ma...
- PubMed ID: 10.3892/or.2020.7770, Knockdown of SERPINE1 reverses resistance of triple‑negative breast cancer to ...
- PubMed ID: 10.3109/15569527.2013.854372, The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1...
- PubMed ID: 10.1111/petr.12984, Cardiometabolic risks vary by weight status in pediatric kidney and liver transp...
- PubMed ID: 10.1097/MD.0000000000002779, Disequilibrium of Blood Coagulation and Fibrinolytic System in Patients With Cor...
- PubMed ID: 10.1007/s12192-015-0634-8, The lost correlation between heat shock protein 70 (HSPA1A) and plasminogen acti...
- PubMed ID: 10.1007/s10528-017-9796-7, The Association of Plasminogen Activator Inhibitor Type 1 (PAI-1) Level and PAI-...
- PubMed ID: 10.1002/ptr.7149, Targeting inflammation-associated AMPK//Mfn-2/MAPKs signaling pathways by baical...
- PubMed ID: 23375586 , Oligodeoxyribonucleotides derived from salmon sperm DNA: an alternative to defib...
- PubMed ID: 25239946 , Nilotinib Does Not Alter the Secretory Functions of Carotid Artery Endothelial C...
- PubMed ID: 16463662 , Expression of connective tissue growth factor in renal tubulointerstitial fibros...
- PubMed ID: 28303356 , The Association of Plasminogen Activator Inhibitor Type 1 (PAI-1) Level and PAI-...
- PubMed ID: 24446892, The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1...
- PubMed ID: 27822905, Associations between homocysteine metabolism related SNPs and carotid intima-med...
- PubMed ID: 26937905, Disequilibrium of Blood Coagulation and Fibrinolytic System in Patients With Cor...
- PubMed ID: 26637413, The lost correlation between heat shock protein 70 (HSPA1A) and plasminogen acti...
- PubMed ID: 24596465, Alterations in the endometrium of rats, rabbits, and?Macaca mulatta?that receive...
- PubMed ID: 29374150, Sun Y, Yang D, Xi L, Chen Y, Fu L, Sun K, Yin J, Li X, Liu S, Qin Y, Liu M, Hou ...
- PubMed ID: 28718192, He, S., Le, N.A., Frediani, J.K., Winterberg, P.D., Jin, R., Liverman, R.,..., &...
- PubMed ID: 25934465, Chen Y, Lu Zj, Yang Y, Lu Gp, Chen Wm, Zhang Le. Thromb Res. 2015 Jul;136(1):131...
*More publications can be found for each product on its corresponding product page