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- Table of Contents
Facts about Substance-P receptor.
The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. .
Human | |
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Gene Name: | TACR1 |
Uniprot: | P25103 |
Entrez: | 6869 |
Belongs to: |
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G-protein coupled receptor 1 family |
NK1R; NK-1R; NK1Rneurokinin 1 receptor; NKIR; SPR; SPRsubstance-P receptor; TAC1R; TAC1Rtachykinin 1 receptor (substance P receptor, neurokinin 1 receptor); tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor); tachykinin receptor 1NK-1 receptor; TACR1
Mass (kDA):
46.251 kDA
Human | |
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Location: | 2p12 |
Sequence: | 2; NC_000002.12 (75046463..75199520, complement) |
Cell membrane; Multi-pass membrane protein.
Are you looking for more information about Boster Bio's Anti-Neurokinin 1 receptor/TACR1 marker? For some optimization tips and techniques, you should read this article. You will also learn more about Substance P receptors and how they can optimize your experiments' results. The Boster Bio website is a good place to start for questions about this biomarker, but don't worry because there's no need to worry. This article will show you how to get the most out of your Boster Bio order.
The anti-Neurokinin1 receptor/TACR1 markers can be used for detecting protein levels in neuronal specimens. This marker is compatible with several types of immunocytochemistry assays. This marker can be used in a variety of clinical situations, including diagnosis of cerebral palsy, ischemic stroke, and neuromuscular diseases. This marker detects the presence TAC1 proteins in the spinal cord.
Boster Biologicals founder Steven Boster launched his business in 1993. Over the years, he has developed numerous products. His first products include several hundred primary antibodies and IHC kits. Boster quickly became the largest Chinese antibody catalog. He then developed the PicoKine(tm) platform, a proprietary ELISA platform that uses trade secrets to develop high-sensitivity ELISA kits.
In biological assays, antibodies for the Substance P receptor are used extensively. These antibodies can react with samples of many animals, and can be monoclonal (or polyclonal) Boster Bio uses rabbit and mouse to develop its Substance-P receptor antibodies. These antibodies can be used in multiple biological assays and provide high-quality results. Visit our website for more information.
In biological assays, the Boster Bio substance-P receptor antibody is used to detect the presence of S-type proteins. The high-molecular-weight bands indicate the presence of direct PKCa substrates. For example, a human liver cell has three subunits, but only one of them is expressed in the cells. Boster Bio substanceP receptor antibodies have an index of high-specificity of approximately 100. This is the highest score these proteins can achieve.
As a result of this approach, Boster Bio has developed 137 rAbs to recognize the 92 synaptic proteins. Each antibody has nanomolar affinity. Some of these antibodies also target specific phosphoprotein residues in proteins. These products have been an important part of the ongoing fight against the opioid crisis.
This collaboration was a result of many researchers. Boster Bio scientists worked together to develop these antibodies. Catherine Woods, who managed the project from screening rabbit antibody libraries to the production and distribution of antibodies, was a close collaborator. Christine Tumanut, who worked in the Boster Bio laboratory, produced the rabbit antibody libraries from sero-positive rabbits. She also coordinated the analysis and compilation of the rabbit rAb data using ELISA. Michelle Liu, Erin Bobeck and Akila Ram all contributed to validation of the antibody library.
These anti-PACs were made using a proprietary method that uses phenyl-clonidine. The antibodies were made from affinity-purified immunoglobulinG and were pre-incubated in 3.2 units of methanol extract CDS per tube. The radioligand were added at eight increasing levels. The assay was run under standard conditions. The results showed the anti-PAC antibody inhibited radioligand binding. No change was observed in affinity constant. Nonspecific binding was not affected.
PMID: 1718267 by Takeda Y., et al. Molecular cloning, structural characterization and functional expression of the human substance P receptor.
PMID: 1659396 by Hopkins B., et al. Isolation and characterisation of the human lung NK-1 receptor cDNA.