Anti-Neurokinin 1 Receptor/TACR1 Antibody
Rabbit IgG polyclonal antibody for Substance-P receptor(TACR1) detection. Tested with WB in Human;Mouse;Rat.
Anti-Neurokinin 1 Receptor/TACR1 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Neurokinin 1 Receptor/TACR1 Antibody
See all NK1R primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for NK1R/TACR1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. NK1R/TACR1 information: Molecular Weight: 46251 MW; Subcellular Localization: Cell membrane; Multi-pass membrane protein.|
|Cite This Product||Anti-Neurokinin 1 Receptor/TACR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1684)|
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|Anti-Neurokinin 1 Receptor/TACR1 Antibody may replace the following items: sc 14115|sc 14116|sc 15323|sc 169414|sc 365091|sc 398126|sc 514453|sc 5218|sc 5220.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human TACR1 (231-245aa DSSDRYHEQVSAKRK), identical to the related rat and mouse sequences.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For TACR1 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||6869|
|Species Of This Entry||Human|
|Protein Name||Substance-P receptor|
|Superfamily||G-protein coupled receptor 1 family|
|Alternative Names||NK1R|NK1R; NK-1R; NK1Rneurokinin 1 receptor; NKIR; SPR; SPRsubstance-P receptor; TAC1R; TAC1Rtachykinin 1 receptor (substance P receptor, neurokinin 1 receptor); tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor); tachykinin receptor 1NK-1 receptor; TACR1|
|Post Tranlational Modifications||Cleavage|
|Subcellular Localization||Cell membrane; Multi-pass membrane protein.|
|Gene Location||2p12, on Chromasome 2, gene sequence: NC_000002.12 (75046463..75199520, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For TACR1 (Source: Uniprot.org, NCBI)
|Protein Function||This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.|
|Research Areas||GPCR; Neuronal Cell Markers; Neuroscience; Neurotransmission|
|Related Diseases||Pain; Anxiety Disorders; Malnutrition; Malignant Neoplasms; Depressive Disorder; Inflammation; Attention Deficit Hyperactivity Disorder; Neoplasms; Cancer Patients And Suicide And Depression; Lung Injury; Nausea And Vomiting; Bipolar Disorder; Schizophrenia; Tissue Adhesions; Nausea; Obesity; Vomiting|
|Related Pathways||Localization; Cell Adhesion; Relaxation Of Vascular Smooth Muscle; Smooth Muscle Contraction; Translation; Sperm Motility; Immune Response; Muscle Contraction; Pathogenesis; Innervation; Secretion|
|Background||The tachykinin receptor 1(TACR1) also known as neurokinin 1 receptor(NK1R) or substance P receptor(SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane(TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.|
|Scientific References||PMID: 1718267 by Takeda Y., et al. Molecular cloning, structural characterization and functional expression of the human substance P receptor.|
PMID: 1659396 by Hopkins B., et al. Isolation and characterisation of the human lung NK-1 receptor cDNA.
Our Boster Quality Guarantee for Anti-Neurokinin 1 Receptor/TACR1 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti TACR1 (PA1684) at 0.5ug/ml
Lane 1: A549 Whole Cell Lysate at 40ug
Lane 2: U87 Whole Cell Lysate at 40ug
Lane 3: COLO320 Whole Cell Lysate at 40ug
Lane 4: SCG Whole Cell Lysate at 40ug
Lane 5: PANC Whole Cell Lysate at 40ug
Predicted bind size: 45KD
Observed bind size: 55KD
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
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- Flow Cytometry Technical Resource Center
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