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- Table of Contents
Facts about Threonine--tRNA ligase, mitochondrial.
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Mouse | |
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Gene Name: | Tars2 |
Uniprot: | Q3UQ84 |
Entrez: | 71807 |
Belongs to: |
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class-II aminoacyl-tRNA synthetase family |
EC 6.1.1.3; mitochondrial; TARSL1; Threonine--tRNA ligase; threonyl-tRNA synthetase 2, mitochondrial (putative); threonyl-tRNA synthetase, mitochondrial; ThrRS
Mass (kDA):
81.7 kDA
Mouse | |
---|---|
Location: | 3|3 F2.1 |
Sequence: | 3; |
This site is a must-read if you are interested to see TARS2 gene Infographics. Gene infographics provide basic information about a gene. The informationgraphics can be used to cover all genes that are found in mice and humans. You can also search for the gene you're interested in by typing the name into the search bar. TARS2 can be used for many purposes.
Boster bio's recent report: Best Uses For The Mouse TARS2 Gene Sequences revealed that this gene is the most commonly sequenced in humans. Its use in gene analysis will likely allow researchers to discover new diseases or better understand existing ones. The TARS2 genes is found in almost all cells in the body. In fact, it is present in over 70 percent of human cells.
Regulating mTORC1 activity requires TARS2 protein. The marker is different from the cytoplasmic threonyl-tRNA synthase (TARS). TARS2 contains 800 mM Thr and Se, while the full-length TARS2 protein has less than half of these amino acid. TARS2 is required to activate MTORC1 in cells without TARS2.
Immunoprecipitation (IP) is used to identify the gene TARS2. Antibodies against this protein target TARS2. IP was performed using an antiHA antibody. An asterisk marks the light IgG chain. EV represents an empty vector. It is recommended that you use the anti-HA antibody as well as a mouse-specific monoclonal antibody when submitting your result. This will ensure that the protein is detected accurately.
The TARS2 gene encodes one member of the class II aminoacyl tRNA synthetase familia. The encoded protein is found in mitochondria. Multiple transcript variants have been identified, indicating alternative splicing. A related pseudogene was found on chromosome 4.
Infographics can be used to visualize many types of information. TARS2 is no exception. The association matrix identifies 468 functional associations between the TARS2 and these entities: organism, disease or trait, chemical, environment, and phenotype. The data was derived 76 datasets. These infographics will explain the significance and help you understand the causes and symptoms of diseases.
The TARS2 protein is necessary for mTORC1 activation. It is not the same TARS, which is cytoplasmic-threonyl tRNA synthetase. TARS2 is required to activate mTORC1, which is a kinase that regulates the regulation of protein synthesis. TARS2 is required to phosphorylate fatty acids and for the synthesis tRNA.
PMID: 16141072 by Carninci P., et al. The transcriptional landscape of the mammalian genome.
PMID: 21183079 by Huttlin E.L., et al. A tissue-specific atlas of mouse protein phosphorylation and expression.