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TBC1D23 Antibodies
AND TBC1D23 ELISA kits, TBC1D23 Proteins
Many biological assays use antibodies to detect TBC1D23, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TBC1D23 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TBC1D23 antibodies...
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TBC1D23 Overview
Facts about TBC1 domain family member 23.
TBC1 domain family member 23 (TBC1D23)
Putative Rab GTPase-activating protein that plays a role in vesicular trafficking (PubMed:28823707). Acts as a bridging protein by binding simultaneously to golgins, such as GOLGA1 and GOLGA4, located in the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197).
Plays a role in brain development, such as in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and freight delivery, 2 processes that are essential for axonal and dendritic growth (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | TBC1D23 |
| Uniprot: | Q9NUY8 |
| Entrez: | 55773 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DKFZp667G062; HCV non-structural protein 4A-transactivated protein 1; HCV nonstructural protein 4A-transactivated protein 1; TBC1 domain family member 23; TBC1 domain family, member 23
Molecular Weight
Mass (kDA):
78.322 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q12.1-q12.2 |
| Sequence: | 3; NC_000003.12 (100260992..100325238) |
Tissue Specificity
Isoform 1: Widely expressed, including in fetal adult brain (corpus callosum, pons, cerebellum), spinal cord, heart, skeletal muscle, thymus and bone marrow, and at lower levels in spleen. Hardly detected in liver, kidney, colon and testis. Isoform 2: Expressed at high levels in liver, kidney, colon and testis. Hardly detected in tissues expressing high levels of isoform 1. Expressed at low levels in spleen.
Subcellular Localizations
Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Localization to the trans-Golgi is regulated by ARL1 and ARL5B/ARL8. ARL1 increases Golgi localization, while ARL5B decreases it. Recruitment to the trans-Golgi network requires the presence of GOLGA1 and GOLGA4, but not that of FAM91A1 (PubMed:29084197, PubMed:28823706). Recruited on AP-1-derived vesicles by WDR11 complex (PubMed:29426865).
Diseases
- Inflammation
- Acquired Immunodeficiency Syndrome
- Cell Transformation, Neoplastic
- Pneumocystis Infections
- Mutation, Out-of-frame
- Communicable Diseases
- High-frequency Microsatellite Instability
- Microsatellite Instability
- Inflammatory Response
- Pneumonia
Interacting Proteins
- CAGE1
- KRTAP10-8
- KRTAP10-9
- KRTAP4-12
- SSBP3
- WDR62
Pathways
- Cytokine Production
- Phagocytosis
- Cell Death
- Immune Response
- Humoral Immune Response
- Rna Interference
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TBC1D23
bosterbio.com/bosterbio-gene-info-cards/TBC1D23
References
PMID: 19077034 by Ishibashi K., et al. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.
PMID: 28823707 by Ivanova E.L., et al. Homozygous truncating variants in TBC1D23 cause pontocerebellar hypoplasia and alter cortical development.