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- Table of Contents
TBX21 Antibodies
AND TBX21 ELISA kits, TBX21 Proteins
Many biological assays use antibodies to detect TBX21, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TBX21 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TBX21 antibodies...
Designing a Western blot for TBX21? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TBX21 Western Blot GuideDesigning an IHC experiment for TBX21? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TBX21 IHC GuideTBX21 Infographic by Boster Bio
All TBX21 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # A00404-1
100 μg/vial
Cat # A00404-1
100 μg/vial
TBX21 Overview
Facts about T-box transcription factor TBX21.
T-box transcription factor TBX21 (TBX21)
Lineage-defining transcription factor that initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, such as those encoding IFN-gamma and the chemokine receptor CXCR3.
Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes such as KDM6B, a SMARCA4- comprising SWI/SNF-complex, and an H3K4me2-methyltransferase complicated for their promoters and all these complexes function to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can trigger Th1 genes also through recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648).
Gene Information
| Human | |
|---|---|
| Gene Name: | TBX21 |
| Uniprot: | Q9UL17 |
| Entrez: | 30009 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Tbet; T-bet; TBETT-PET; TBLYM; TBLYMT-cell-specific T-box transcription factor T-bet; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; TBX21; T-PET; Transcription factor TBLYM
Molecular Weight
Mass (kDA):
58.328 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.32 |
| Sequence: | 17; NC_000017.11 (47733236..47746122) |
Tissue Specificity
T-cell specific.
Subcellular Localizations
Nucleus.
Diseases
- Autoimmune Reaction
- Asthma
- Inflammation
- Autoimmune Diseases
- Malignant Neoplasms
- Sclerosis
- Autoimmunity
- Neoplasms
- Hepatitis
- Dysequilibrium Syndrome
- Childhood Asthma
- Arthritis
- Infective Disorder
Interacting Proteins
- CREBBP
- EP300
- GATA3
- SP1
Pathways
- Pathogenesis
- Cell Differentiation
- Immune Response
- Cytokine Production
- Secretion
- Cell Activation
- Cell Development
- Methylation
- T Cell Differentiation
- T Cell Activation
- Hypersensitivity
- Reverse Transcription
- Cell Cycle
PTMs
- Methylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TBX21
bosterbio.com/bosterbio-gene-info-cards/TBX21
References
PMID: 10761931 by Szabo S.J., et al. A novel transcription factor, T-bet, directs Th1 lineage commitment.
PMID: 15806396 by Akahoshi M., et al. Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.
2 Publications of Boster TBX21 Antibodies & ELISA Kits
- PubMed ID: 10.1152/ajplung.00409.2016, Impaired TNF/TNFR2 signaling enhances Th2 and Th17 polarization and aggravates a...
- PubMed ID: 23056858, Miao L, Run-Ming J, Yi J. Iran J Pediatr. 2012 Mar;22(1):43-51. T-Bet Mediated A...
*More publications can be found for each product on its corresponding product page