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Tdrd9 Antibodies
AND Tdrd9 ELISA kits, Tdrd9 Proteins
Many biological assays use antibodies to detect Tdrd9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tdrd9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tdrd9 antibodies...
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Tdrd9 Infographic by Boster Bio
All Tdrd9 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A11411
100 μg/vial
Cat # A11411
100 μg/vial
Tdrd9 Overview
Facts about ATP-dependent RNA helicase TDRD9.
ATP-dependent RNA helicase TDRD9 (Tdrd9)
ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:20059948, PubMed:28633017). Acts through the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20059948, PubMed:28633017).
Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector from the nucleus together with PIWIL4 (PubMed:28633017). .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Tdrd9 |
| Uniprot: | Q14BI7 |
| Entrez: | 74691 |
Family
| Belongs to: |
|---|
| DEAD box helicase family |
Alternative Names
C14orf75; chromosome 14 open reading frame 75; DKFZp434N0820; EC 3.6.1; EC 3.6.4.13; FLJ36164; HIG-1; hypoxia-inducible HIG-1; MGC135025; NET54; putative ATP-dependent RNA helicase TDRD9; tudor domain containing 9; Tudor domain-containing protein 9
Molecular Weight
Mass (kDA):
155.98 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 12|12 F1 |
| Sequence: | 12; |
Tissue Specificity
Predominantly expressed in reproductive organs. Detected in mitotic spermatogonia, meiotic spermatocytes (predominantly at the pachytene stage), haploid spermatids in the testis, and in growing oocytes in the ovary (at protein level).
Diseases
- Sterility
- Cataract
- Male Infertility
- Azoospermia
- Cryptorchidism
- Precocious Puberty
- Senile Cataract
- Genomic Instability
Pathways
- Localization
- Methylation
- Cell Death
- Dna Methylation
- Dna Demethylation
- Spermatid Development
- Meiosis
PTMs
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tdrd9
bosterbio.com/bosterbio-gene-info-cards/Tdrd9
References
PMID: 20059948 by Shoji M., et al. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
PMID: 19584108 by Vagin V.V., et al. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.