TEX14 Antibodies

AND TEX14 ELISA kits, TEX14 Proteins

Many biological assays use antibodies to detect TEX14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TEX14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TEX14 antibodies...

We validate the specificity of these antibodies to TEX14 by testing them on tissues known to express TEX14 positively and negatively. Browse below to find the TEX14 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TEX14 Infographic by Boster Bio

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TEX14 (NM_031272) Human Over-expression Lysate

Human

$960
Cat # LS056155
20 µg, 100 µg

TEX14 Overview

Facts about Inactive serine/threonine-protein kinase TEX14.

TEX14 3D structure. Source: alphafold

Inactive serine/threonine-protein kinase TEX14 (TEX14)

Required both for the formation of intercellular bridges throughout meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility.

Acts by promoting the conversion of midbodies into intercellular bridges through its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment.

Gene Information

Human
Gene Name:	TEX14
Uniprot:	Q8IWB6
Entrez:	56155

Family

Belongs to:

protein kinase superfamily

Alternative Names

cancer/testis antigen 113; CT113; Protein kinase-like protein SgK307; SGK307; Sugen kinase 307; testis expressed 14; testis expressed sequence 14; testis-expressed protein 14; Testis-expressed sequence 14

Molecular Weight

Mass (kDA):
167.901 kDA

Genomic Context


Human

Location:	17q22
Sequence:	17; NC_000017.11 (58556677..58692055, complement)

Tissue Specificity

Expression restricted to testis.

Subcellular Localizations

Cytoplasm. Midbody. Chromosome, centromere, kinetochore. Detected in the intercellular bridges that connect male germ cell daughter cells after cell division.

Diseases

Male Infertility
Infertility
Neoplasms
Oligospermia
Congenital Abnormality
Malignant Neoplasm Of Breast
Spermatogenesis Arrest
Malignant Paraganglionic Neoplasm
Idiopathic Pneumonia Syndrome
Partial Deletion Of Y

Sterility
Multiple Myeloma
Malignant Neoplasms
Mammary Neoplasms
Cytogenetic Abnormality

Interacting Proteins

CEP55
LMO4

Pathways

Spermatogenesis
Cytokinesis
Meiosis
Abscission
Pachytene
Translation
Localization
Transport
Chromosome Separation
Sex Determination
Dosage Compensation
Chromosome Segregation
Cell Division

Rna Transport
Cell Differentiation
Cell Communication
Spindle Assembly Checkpoint
Gonad Development
Spindle Assembly
Diplotene

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TEX14

References

PMID: 11279525 by Wang P.J., et al. An abundance of X-linked genes expressed in spermatogonia.

PMID: 12711554 by Wu M.-H., et al. Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis.