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Facts about Toll-like receptor 7.
TLR7 is a nucleotide-sensing TLR that's triggered by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Human | |
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Gene Name: | TLR7 |
Uniprot: | Q9NYK1 |
Entrez: | 51284 |
Belongs to: |
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Toll-like receptor family |
TLR7; toll-like receptor 7
Mass (kDA):
120.922 kDA
Human | |
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Location: | Xp22.2 |
Sequence: | X; NC_000023.11 (12867072..12890361) |
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
If you're searching for a high-quality toll-like receptor antibody, you'll want to read this Boster Bio review. This review will cover Boster Bio, Toll-like receptor 7, CoVac501, Validation, and more. Boster is a company that rewards the first reviewers of its products with product credits. Boster also offers a generous rewards program for scientists worldwide.
Oxoadenine compounds are novel TLR7/8 agonists that have been found to improve the immune response to antigens. In vitro studies have shown that these compounds are superior to other TLR agonists due to their high potency and relatively low inflammatory cytokine profiles. Oxoadenine 7 has the potential to be an adjuvant for the development of new vaccines.
Toll-like receptors recognize single-stranded viral RNA. Their binding domains initiate downstream transcription factors that activate proinflammatory cytokines, type I interferons, and co-stimulatory molecules. These receptors then cause dendritic cells to mature and present antigens. The precise transcriptional changes and stimuli are critical to the development of a robust immune response. TLR7/IL-2 and other cytokines are key components of cell-mediated immunity.
In a study that focused on the TLR7/TLR8 marker, compound 7 was synthesized by attaching a methyl group to the 2-O-butyl side chain. In the same study, compound 7 induced lower IFNa and TNFa than compound 4, but induced the same levels of IFNa. These results support the hypothesis that the cytokine environment shapes the adaptive immune response.
A new study demonstrates that TLR7/8 agonists enhance the production of antigen-specific antibodies. The effect of TLR7/8 agonists was dose dependent. Pigs vaccinated with the highest dose of adjuvant developed an immune response 13-fold higher than that of non-vaccine-adjuvants. As a result, novel TLR7/8 agonists may be useful vaccine adjuvants.
The Toll-like receptor 7 (TLR7) gene encodes a protein found in both mammals and birds that plays a crucial role in pathogen recognition and activation of innate immunity. Though highly conserved from Drosophila to humans, Toll-like receptors have varying patterns of expression and are not identical in all species. In addition, they respond to different pathogen-associated molecular patterns.
The TLR7 Marker is a member of the family of Toll-like receptors. The antibody used to detect this protein is the boster bio anti-Toll-like receptor 7 (PA1733). This antibody is validated on multiple platforms for its specificity and high affinity. The company rewards the first reviewer with product credits. This honor is extended to scientists worldwide.
In a recent study, a TLR7-deficient mouse did not produce autoantibody responses to the pristane model of SLE. In addition to autoantibody production, mice lacking TLR7 also do not produce responses to other viral pathogens, including HIV. These results suggest that TLR7 carries the potential to play a role in the onset of autoimmune diseases.
The validation of the TLR7 marker in Boster's ELISA kits demonstrates high sensitivity and specificity. The image and validation procedure can be accessed upon request. For IHC, the supervision(tm) system saves 30 minutes and improves background. Lastly, the Picoband(tm) technology is powered by insights in the design of the best immunogen. And, like all of Boster's products, this one comes backed by extensive technical support.
This Boster Bio TLR7 antibody demonstrates good cross-reactivity between various cell lines and tissues. Reactions were observed in a rat, mouse, and human sample, and the TLR7 antibody was found to react with these cells. Furthermore, this antibody binds to both human and murine TLR7 mRNA. As a result, the TLR7 anti-Toll-like receptor 7 marker was highly specific in Boster bio's TLR7-antibody.
In a subsequent study, the TLR7-deficient antibody 24F4A inhibited IFNa production by pDCs, which is important for assessing the therapeutic efficacy of new drugs. Further, the results showed that 24F4A-ef is 40-fold more potent than synthetic TLR7 ligands. It had an IC50 of 1.3 mg/ml, making it potent at inhibiting IFNa production.
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PMID: 11022119 by Du X., et al. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution.
PMID: 11022120 by Chuang T.-H., et al. Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9.
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