Anti-Toll-like receptor 7 TLR7 Antibody
Rabbit IgG polyclonal antibody for Toll-like receptor 7(TLR7) detection. Tested with WB, IHC-P in Human;Rat;Mouse.
Anti-Toll-like receptor 7 TLR7 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Toll-like receptor 7 TLR7 Antibody
See all TLR7 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for TLR7 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. TLR7 information: Molecular Weight: 120922 MW; Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist; Tissue Specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.|
|Cite This Product||Anti-Toll-like receptor 7 TLR7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1733)|
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|Anti-Toll-like receptor 7 TLR7 Antibody may replace the following items: sc 16245|sc 13207|sc 13208|sc 30004|sc 57463.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human TLR7(1020-1038aa QAHPYFWQCLKNALATDNH), different from the related rat and mouse sequences by one amino acid.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For TLR7 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||51284|
|Species Of This Entry||Human|
|Protein Name||Toll-like receptor 7|
|Superfamily||Toll-like receptor family|
|Alternative Names||TLR7|TLR7; toll-like receptor 7|
|Post Tranlational Modifications||Phosphorylation; Methylation; Phosphorothioation; Cleavage; Ubiquitination; Glycosylation; Reduction; Oxidation; Sumoylation; Hydroxylation; Amidation; Acetylation|
|Subcellular Localization||Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.|
|Gene Location||Xp22.2, on Chromasome X, gene sequence: NC_000023.11 (12867072..12890361)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For TLR7 (Source: Uniprot.org, NCBI)
|Protein Function||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).|
|Tissue Specificity||Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.|
|Research Areas||Cytokine Research; Immunology; Innate Immunity|
|Related Diseases||Virus Diseases; Inflammation; Infective Disorder; Innate Immune Response; Autoimmune Reaction; Malignant Neoplasms; Neoplasms; Lupus Erythematosus, Systemic; Autoimmune Diseases; Influenza; Autoimmunity; Hiv Infections; Hepatitis; Inflammatory Response; Hepatitis C; Carcinoma; Asthma; Melanoma; Communicable Diseases; Immunologic Deficiency Syndromes|
|Related Pathways||Immune Response; Secretion; Cytokine Production; Pathogenesis; Innate Immune Response; Cell Activation; Inflammatory Response; Cell Proliferation; Viral Replication; Localization; Cytokine Secretion; Adaptive Immune Response; Rna Interference; Phagocytosis; Cell Death; Cell Differentiation; Sensitization; Type I Interferon Production; B Cell Activation; B Cell Proliferation|
|Background||TLR7(Toll-like receptor 7) is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds. TLR7 is a member of the Toll-like receptor(TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns(PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X. TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.|
|Scientific References||PMID: 11022119 by Du X., et al. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution.|
PMID: 11022120 by Chuang T.-H., et al. Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9.
Our Boster Quality Guarantee for Anti-Toll-like receptor 7 TLR7 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Rat Spleen Tissue Lysate
Lane 2: Rat Liver Tissue Lysate
Lane 3: U87 Cell Lysate
Lane 4: A549 Cell Lysate
IHC(P): Human Placenta Tissue
IHC(P): Rat Spleen Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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