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TNFRSF10A Antibodies
AND TNFRSF10A ELISA kits, TNFRSF10A Proteins
Many biological assays use antibodies to detect TNFRSF10A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNFRSF10A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNFRSF10A antibodies...
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TNFRSF10A Infographic by Boster Bio
All TNFRSF10A Products
Product
Figures
Specificity
Applications
Price
Anti-DR4/TNFRSF10A Antibody Picoband®
5 Citations
Human, Mouse, Rat
IF, ICC, WB
$370
Cat # A02152
100 μg/vial
Cat # A02152
100 μg/vial
Human
Flow Cytometry, IP, ICC
$330
Cat # M02152
0.1 mg
Cat # M02152
0.1 mg
Human
WB
$523
Cat # M02152-1
100 µl
Cat # M02152-1
100 µl
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M02152-2
100 μg
Cat # M02152-2
100 μg
TNFRSF10A Overview
Facts about Tumor necrosis factor receptor superfamily member 10A.
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor.
The consequent death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Gene Information
| Human | |
|---|---|
| Gene Name: | TNFRSF10A |
| Uniprot: | O00220 |
| Entrez: | 8797 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
APO2; CD261 antigen; CD261; cytotoxic TRAIL receptor; Death receptor 4; DR4 TRAIL receptor 1; DR4; TNF-related apoptosis inducing ligand receptor 1; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAILR1; TRAIL-R1; TRAILR-1; TRAILR1MGC9365; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily, member 10a
Molecular Weight
Mass (kDA):
50.089 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.3 |
| Sequence: | 8; NC_000008.11 (23190452..23225102, complement) |
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Leukemia
- Adenocarcinoma
- Prostatic Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Prostate
- Malignant Tumor Of Colon
- Lymphoma
- Colonic Neoplasms
- Lung Neoplasms
Interacting Proteins
- ARAP1
- CASP8
- LGALS3BP
- TNFSF10
Pathways
- Cell Death
- Induction Of Apoptosis
- Sensitization
- Pathogenesis
- Cell Proliferation
- Cell Cycle
- Methylation
- Programmed Cell Death
- Localization
- Cell Growth
- Rna Interference
- Cell Killing
- Endocytosis
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Demethylation
- Glycosylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFRSF10A
bosterbio.com/bosterbio-gene-info-cards/TNFRSF10A
References
PMID: 9082980 by Pan G., et al. The receptor for the cytotoxic ligand TRAIL.
PMID: 9430227 by Chaudhary P.M., et al. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.
4 Publications of Boster TNFRSF10A Antibodies & ELISA Kits
- PubMed ID: 10.1371/journal.pone.0079384, The Novel Fusion Proteins, GnRH-p53 and GnRHIII-p53, Expression and Their Anti-T...
- PubMed ID: 18277875, Zhang L, Niu T, Yang Sy, Lu Z, Chen B. Spine (Phila Pa 1976). 2008 Feb 15;33(4):...
- PubMed ID: 21785459, Fu K, Ren H, Wang Y, Fei E, Wang H, Wang G. Oncogene. 2012 Mar 8;31(10):1311-22....
- PubMed ID: 24970806, Liu N, Zuo C, Wang X, Chen T, Yang D, Wang J, Zhu H. Oncotarget. 2014 Jul 15;5(1...
*More publications can be found for each product on its corresponding product page