Anti-DR4/TNFRSF10A Antibody

Boster Bio Anti-DR4/TNFRSF10A Antibody catalog # PA1975. Tested in WB applications. This antibody reacts with Human. Cited in 3 publication(s).

Product Info Summary

SKU: PA1975
Size: 100μg/vial
Reactive Species: Human
Host: Rabbit
Application: WB

Product Name

Anti-DR4/TNFRSF10A Antibody

See all TRAILR1/TNFRSF10A products

SKU/Catalog Number

PA1975

Size

100μg/vial

Form

Lyophilized

Description

Boster Bio Anti-DR4/TNFRSF10A Antibody catalog # PA1975. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-DR4/TNFRSF10A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1975)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human DR4 (110-125aa TIKLHDQSIGTQQWEH).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross Reactivity

No cross reactivity with other proteins

Reactive Species

PA1975 is reactive to TNFRSF10A in Human

Applications

PA1975 is guaranteed for WB Boster Guarantee

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For TNFRSF10A (Source: Uniprot.Org, NCBI)

Uniprot ID

O00220

Gene ID

8797

Gene Name

TNFRSF10A

Full Name

Tumor necrosis factor receptor superfamily member 10A

Weight

50.089kDa

Alternative Names

APO2; CD261 antigen; CD261; cytotoxic TRAIL receptor; Death receptor 4; DR4 TRAIL receptor 1; DR4; TNF-related apoptosis inducing ligand receptor 1; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAILR1; TRAIL-R1; TRAILR-1; TRAILR1MGC9365; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily, member 10a TNFRSF10A APO2, CD261, DR4, TRAILR-1, TRAILR1 TNF receptor superfamily member 10a tumor necrosis factor receptor superfamily member 10A|TNF-related apoptosis-inducing ligand receptor 1|TRAIL receptor 1|TRAIL-R1|cytotoxic TRAIL receptor|death receptor 4|tumor necrosis factor receptor superfamily member 10a variant 2|tumor necrosis factor receptor superfamily, member 10a

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on TNFRSF10A, check out the TNFRSF10A Infographic

TNFRSF10A infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for TNFRSF10A: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

PA1975 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Zhang L, Niu T, Yang Sy, Lu Z, Chen B. Spine (Phila Pa 1976). 2008 Feb 15;33(4):422-7. Doi: 10.1097/Brs.0B013E318163E036. The Occurrence And Regional Distribution Of Dr4 On Herniated Disc Cells: A Potential Apoptosis Pathway In Lumbar Intervertebr...

Fu K, Ren H, Wang Y, Fei E, Wang H, Wang G. Oncogene. 2012 Mar 8;31(10):1311-22. Doi: 10.1038/Onc.2011.315. Epub 2011 Jul 25. Dj-1 Inhibits Trail-Induced Apoptosis By Blocking Pro-Caspase-8 Recruitment To Fadd.

Liu N, Zuo C, Wang X, Chen T, Yang D, Wang J, Zhu H. Oncotarget. 2014 Jul 15;5(13):4959-71. Mir-942 Decreases Trail-Induced Apoptosis Through Isg12A Downregulation And Is Regulated By Akt.

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6 Customer Q&As for Anti-DR4/TNFRSF10A Antibody

Question

I see that the anti-DR4/TNFRSF10A antibody PA1975 works with WB, what is the protocol used to produce the result images on the product page?

Verified Customer

Verified customer

Asked: 2020-01-01

Answer

You can find protocols for WB on the "support/technical resources" section of our navigation menu. If you have any further questions, please send an email to [email protected]

Boster Scientific Support

Answered: 2020-01-01

Question

We are currently using anti-DR4/TNFRSF10A antibody PA1975 for human tissue, and we are well pleased with the WB results. The species of reactivity given in the datasheet says human. Is it true that the antibody can work on zebrafish tissues as well?

Verified Customer

Verified customer

Asked: 2019-12-26

Answer

The anti-DR4/TNFRSF10A antibody (PA1975) has not been validated for cross reactivity specifically with zebrafish tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in zebrafish you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-12-26

Question

Thank you for helping with my inquiry over the phone. Here are the WB image, lot number and protocol we used for colon carcinoma using anti-DR4/TNFRSF10A antibody PA1975. Let me know if you need anything else.

T. Parker

Verified customer

Asked: 2018-04-17

Answer

Thank you for the data. You have provided everything we needed. Our lab team are working to resolve your inquiry as quickly as possible, and we appreciate your patience and understanding! Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2018-04-17

Question

Does PA1975 anti-DR4/TNFRSF10A antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?

Verified Customer

Verified customer

Asked: 2017-11-13

Answer

You can see on the product datasheet, PA1975 anti-DR4/TNFRSF10A antibody as been validated on WB. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.

Boster Scientific Support

Answered: 2017-11-13

Question

I was wanting to use your anti-DR4/TNFRSF10A antibody for WB for human colon carcinoma on frozen tissues, but I want to know if it has been validated for this particular application. Has this antibody been validated and is this antibody a good choice for human colon carcinoma identification?

Verified Customer

Verified customer

Asked: 2017-09-07

Answer

It shows on the product datasheet, PA1975 anti-DR4/TNFRSF10A antibody has been tested for WB on human tissues. We have an innovator award program that if you test this antibody and show it works in human colon carcinoma in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2017-09-07

Question

Does anti-DR4/TNFRSF10A antibody PA1975 work for WB with colon carcinoma?

M. Jackson

Verified customer

Asked: 2014-11-13

Answer

According to the expression profile of colon carcinoma, TNFRSF10A is highly expressed in colon carcinoma. So, it is likely that anti-DR4/TNFRSF10A antibody PA1975 will work for WB with colon carcinoma.

Boster Scientific Support

Answered: 2014-11-13

Size

Total: $315

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PA1975
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$315.00

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