Many biological assays use antibodies to detect Tenascin-N, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tenascin-N in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tenascin-N antibodies...
We validate the specificity of these antibodies to Tenascin-N by testing them on tissues known to express TNN positively and negatively. Browse below to find the TNN antibody that suites your experiment. We have 61 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Extracellular matrix protein which seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity) (PubMed:17909022). Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity).
During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling (By similarity). In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
Gene Information
Human
Gene Name:
TNN
Uniprot:
Q9UQP3
Entrez:
63923
Family
Belongs to:
tenascin family
Alternative Names
tenascin N
Molecular Weight
Mass (kDA): 144.034 kDA
Genomic Context
Human
Location:
1q25.1
Sequence:
1; NC_000001.11 (175067833..175148075)
Tissue Specificity
Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327).
For details, visit: bosterbio.com/bosterbio-gene-info-cards/TNN
References
PMID: 17909022 by Degen M., et al. Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior.
PMID: 19884327 by Martina E., et al. Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro.
3 Publications of Boster Tenascin-N Antibodies & ELISA Kits
PubMed ID: 10.3892/mmr.2012.1185, Recombinant human brain natriuretic peptide therapy combined with bone mesenchym...