Tenascin-R (TNR)

Neural extracellular matrix (ECM) protein involved in interactions with unique cells and matrix components. These interactions may influence cellular behavior by evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth.

Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and leads to an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides leads to a oligodendrocyte adhesion and differentiation.