Anti-Tenascin-R TNR Antibody
Rabbit IgG polyclonal antibody for Tenascin-R(TNR) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Anti-Tenascin-R TNR Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Tenascin-R TNR Antibody
See all Tenascin R primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for Tenascin R/TNR detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. Tenascin R/TNR information: Molecular Weight: 149562 MW; Subcellular Localization: Secreted, extracellular space, extracellular matrix; Tissue Specificity: Brain specific.|
|Cite This Product||Anti-Tenascin-R TNR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1695-1)|
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|Anti-Tenascin-R TNR Antibody may replace the following items: sc 366099|sc 107682|sc 130798|sc 366099 X|sc 107682 X.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of mouse TNR(104-117aa QTSDHESQVTFTHK), identical to the related rat sequence, and different from the related human sequence by one amino acid.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For TNR (Source: Uniprot.org, NCBI)
|NCBI Gene Id||7143|
|Species Of This Entry||Human|
|Alternative Names||Tenascin R|Janusin; MGC149328; Restrictin; tenascin R (restrictin, janusin); Tenascin R; tenascin-R; TNR; TN-R|
|Post Tranlational Modifications||Cleavage; Hydroxylation; Oxidation; Demethylation; Nitration; Reduction|
|Subcellular Localization||Secreted, extracellular space, extracellular matrix.|
|Gene Location||1q25.1, on Chromasome 1, gene sequence: NC_000001.11 (175315194..175743702, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For TNR (Source: Uniprot.org, NCBI)
|Protein Function||Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). .|
|Tissue Specificity||Brain specific.|
|Related Diseases||Trinucleotide Repeat Expansion; Neurodegenerative Disorders; Neoplasms; Huntington Disease; Ataxia; Schizophrenia; Ataxia, Spinocerebellar; Liver Neoplasms; Malignant Neoplasms; Carcinoma; Liver Carcinoma; Atrophy; Rhinorrhea; Genomic Instability; Nervousness; Nervous System Disorder; Dystrophy; Myotonic Dystrophy; Neoplasm Metastasis; Cat Diseases|
|Related Pathways||Dna Replication; Dna Repair; Mismatch Repair; Pathogenesis; Translation; Chromosome Breakage; Regeneration; Brain Development; Double-strand Break Repair; Cell Cycle; Cell Proliferation; Synaptic Transmission; Localization; Innervation; Transport; Cell Migration; Electron Transport; Immune Response; Axon Regeneration; Pigmentation|
|Background||Tenascin-R is a protein that in humans is encoded by the TNR gene. Tenascin-R(TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin(TN) gene family, which includes at least 3 genes in mammals: TNC(or hexabrachion), TNX(TNXB), and TNR. The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues. TNR has been detected predominantly in the central nervous system and is localized around motor neurons and on motor axons in the spinal cord, cerebellum, hippocampus, and olfactory bulb. It is suggested that tenascin-R has a role in initiating the detachment of neuroblasts from tangential chains and in initiating radial migration of the cells.|
|Scientific References||PMID: 8626505 by Carnemolla B., et al. Human tenascin-R: complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24.|
Our Boster Quality Guarantee for Anti-Tenascin-R TNR Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Rat, Human, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
IHC(P): Rat Brain Tissue
All lanes: Anti TNR (PA1695-1) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: U87 Whole Cell Lysate at 40ug
Lane 3: HELA Whole Cell Lysate at 40ug
Lane 4: MCF-7 Whole Cell Lysate at 40ug
Predicted bind size: 150KD
Observed bind size: 150KD
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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