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- Table of Contents
TREX1 Antibodies
AND TREX1 ELISA kits, TREX1 Proteins
Many biological assays use antibodies to detect TREX1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TREX1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TREX1 antibodies...
Designing a Western blot for TREX1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TREX1 Western Blot GuideTREX1 Infographic by Boster Bio
All TREX1 Products
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Specificity
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TREX1 Overview
Facts about Three-prime repair exonuclease 1.
Three-prime repair exonuclease 1 (TREX1)
Major mobile 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Acts by metabolizing DNA fragments from endogenous retroelements, such as L1, LTR and SINE elements.
Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) reaction and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates.
Gene Information
| Human | |
|---|---|
| Gene Name: | TREX1 |
| Uniprot: | Q9NSU2 |
| Entrez: | 11277 |
Family
| Belongs to: |
|---|
| exonuclease superfamily |
Alternative Names
3'-5' exonuclease TREX1; AGS1; Aicardi-Goutieres syndrome 1; CRV; DKFZp434J0310; DNase III; DRN3; EC 3.1.11.2; HERNS; three prime repair exonuclease 1,3' repair exonuclease 1
Molecular Weight
Mass (kDA):
33.212 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.31 |
| Sequence: | 3; NC_000003.12 (48465830..48467645) |
Tissue Specificity
Detected in thymus, spleen, liver, brain, heart, small intestine and colon.
Subcellular Localizations
Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Retained in the cytoplasm through the C-terminal region (By similarity). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci. Translocation to the nucleus also occurs during GZMA-mediated cell death.
Diseases
- Lupus Erythematosus, Systemic
- Autoimmune Diseases
- Chilblains
- Autoimmune Reaction
- Autoimmunity
- Chilblain Lupus Erythematosus
- Innate Immune Response
- Autoimmune Diseases Of The Nervous System
- Brain Diseases
- Virus Diseases
- Encephalopathies
- Congenital Neurologic Anomalies
Interacting Proteins
- KRTAP10-7
Pathways
- Immune Response
- Pathogenesis
- Innate Immune Response
- Dna Repair
- Dna Replication
- Cell Death
- Localization
- Reverse Transcription
- Mismatch Repair
- Aging
- Pigmentation
- Adaptive Immune Response
PTMs
- Cleavage
Research Areas
- DNA Repair
- Editing and Processing Endonucleases
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TREX1
bosterbio.com/bosterbio-gene-info-cards/TREX1
References
PMID: 10393201 by Hoess M., et al. A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein.
PMID: 10391904 by Mazur D.J., et al. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.