TRPC4 Antibodies

AND TRPC4 ELISA kits, TRPC4 Proteins

Many biological assays use antibodies to detect TRPC4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPC4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPC4 antibodies...

We validate the specificity of these antibodies to TRPC4 by testing them on tissues known to express TRPC4 positively and negatively. Browse below to find the TRPC4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRPC4 Infographic by Boster Bio

All TRPC4 Products

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Product

Figures

Specificity

Applications

Price

Anti-TRPC4 Antibody Picoband®

1 Citations 5 Q&As

Anti-TRPC4 antibody, PA2307, All Western blottingAll lanes: Anti-TRPC4(PA2307) at 0

Human

$370
Cat # PA2307
100 μg/vial

Anti-TRPC4 Antibody Picoband®

Western blot analysis of TRPC4 using anti-TRPC4 antibody (A02037-1)

Human, Mouse, Rat

$370
Cat # A02037-1
100 μg/vial

TRPC4 (NM_016179) Human Over-expression Lysate

Human

$960
Cat # LS007223
20 µg, 100 µg

TRPC4 Overview

Facts about Short transient receptor potential channel 4.

TRPC4 3D structure. Source: alphafold

Short transient receptor potential channel 4 (TRPC4)

Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel.

Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium.

Gene Information

Human
Gene Name:	TRPC4
Uniprot:	Q9UBN4
Entrez:	7223

Family

Belongs to:

transient receptor (TC 1.A.4) family

Alternative Names

hTrp4; hTrp-4; MGC119570; MGC119571; MGC119572; MGC119573; short transient receptor potential channel 4; transient receptor potential 4; transient receptor potential cation channel, subfamily C, member 4; TRP4HTRP4; TrpC4; Trp-related protein 4

Molecular Weight

Mass (kDA):
112.101 kDA

Genomic Context


Human

Location:	13q13.3
Sequence:	13; NC_000013.11 (37632063..37869772, complement)

Tissue Specificity

Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.

Subcellular Localizations

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Enhanced insertion into the cell membrane after activation of the EGF receptor.

Diseases

Hypertensive Disease
Hypoxia
Pain
Pathologic Vasoconstriction
Nervousness
Pulmonary Hypertension
Tumor Angiogenesis
Hypertrophy
Vascular Diseases
Malignant Neoplasms
Cardiovascular Diseases
Asthma

Columnar Cell Hyperplasia Of The Breast
Inflammation
Vascular System Injuries
Pathologic Neovascularization
Hyperalgesia
Anoxia
Ischemia

Interacting Proteins

Pathways

Localization
Store-operated Calcium Entry
Transport
Cell Proliferation
Secretion
Vasoconstriction
Muscle Contraction
Angiogenesis
Smooth Muscle Contraction
Synaptic Transmission
Rna Interference
Cellular Localization
Cell Death

Regulation Of Vascular Permeability
Axon Guidance
Regeneration
Hypersensitivity
Endothelial Cell Proliferation
Endoplasmic Reticulum Organization
Cell Differentiation

PTMs

Phosphorylation
Biotinylation

Nitrosylation
Cleavage

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPC4

References

PMID: 11042129 by McKay R.R., et al. Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3.

PMID: 11163362 by Mery L., et al. Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.