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- Table of Contents
TRPC4 Antibodies
AND TRPC4 ELISA kits, TRPC4 Proteins
Many biological assays use antibodies to detect TRPC4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPC4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPC4 antibodies...
Designing a Western blot for TRPC4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TRPC4 Western Blot GuideTRPC4 Infographic by Boster Bio
All TRPC4 Products
Product
Figures
Specificity
Applications
Price
Anti-c-Jun/JUN Antibody Picoband®
5 Citations
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02038-3
100 μg/vial
Cat # A02038-3
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02039-1
100 μg/vial
Cat # A02039-1
100 μg/vial
TRPC4 Overview
Facts about Short transient receptor potential channel 4.
Short transient receptor potential channel 4 (TRPC4)
Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel.
Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRPC4 |
| Uniprot: | Q9UBN4 |
| Entrez: | 7223 |
Family
| Belongs to: |
|---|
| transient receptor (TC 1.A.4) family |
Alternative Names
hTrp4; hTrp-4; MGC119570; MGC119571; MGC119572; MGC119573; short transient receptor potential channel 4; transient receptor potential 4; transient receptor potential cation channel, subfamily C, member 4; TRP4HTRP4; TrpC4; Trp-related protein 4
Molecular Weight
Mass (kDA):
112.101 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q13.3 |
| Sequence: | 13; NC_000013.11 (37632063..37869772, complement) |
Tissue Specificity
Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
Subcellular Localizations
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Enhanced insertion into the cell membrane after activation of the EGF receptor.
Diseases
- Hypertensive Disease
- Hypoxia
- Pain
- Pathologic Vasoconstriction
- Nervousness
- Pulmonary Hypertension
- Tumor Angiogenesis
- Hypertrophy
- Vascular Diseases
- Malignant Neoplasms
- Cardiovascular Diseases
- Asthma
Interacting Proteins
- MX1
Pathways
- Localization
- Store-operated Calcium Entry
- Transport
- Cell Proliferation
- Secretion
- Vasoconstriction
- Muscle Contraction
- Angiogenesis
- Smooth Muscle Contraction
- Synaptic Transmission
- Rna Interference
- Cellular Localization
- Cell Death
PTMs
- Phosphorylation
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPC4
bosterbio.com/bosterbio-gene-info-cards/TRPC4
References
PMID: 11042129 by McKay R.R., et al. Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3.
PMID: 11163362 by Mery L., et al. Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.
4 Publications of Boster TRPC4 Antibodies & ELISA Kits
- PubMed ID: 10.1186/1479-5876-11-32, Hirsutanol A, a novel sesquiterpene compound from fungus Chondrostereum sp., ind...
- PubMed ID: 10.1016/j.tiv.2016.12.016, Alterations in transcription and protein expressions of HCC-related genes in Hep...
- PubMed ID: 10.1007/s10565-008-9054-1, Genistein induces G 2 /M cell cycle arrest via stable activation of ERK1/2 pathw...
- PubMed ID: 34164500, Yi J,Tian M,Hu L,Kang N,Ma W,Zhi J,Zheng X,Ruan X,Gao M.The mechanisms of celast...
*More publications can be found for each product on its corresponding product page