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TRPM8 Antibodies
AND TRPM8 ELISA kits, TRPM8 Proteins
Many biological assays use antibodies to detect TRPM8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPM8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPM8 antibodies...
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TRPM8 Overview
Facts about Transient receptor potential cation channel subfamily M member 8.
Transient receptor potential cation channel subfamily M member 8 (TRPM8)
Receptor-activated non-selective cation channel involved in detection of sensations like coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH.
Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRPM8 |
| Uniprot: | Q7Z2W7 |
| Entrez: | 79054 |
Family
| Belongs to: |
|---|
| transient receptor (TC 1.A.4) family |
Alternative Names
CMR1; Long transient receptor potential channel 6; LTRPC6; LTrpC-6; MGC2849; short form of the TRPM8 cationic channel; transient receptor potential cation channel, subfamily M, member 8; Transient receptor potential p8; transient receptor potential subfamily M member 8; TRPM8; TRPP8; trp-p8; TRPP8transient receptor potential cation channel subfamily M member 8
Molecular Weight
Mass (kDA):
127.685 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.1 |
| Sequence: | 2; NC_000002.12 (233917342..234019522) |
Tissue Specificity
Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells.
Diseases
- Pain
- Malignant Neoplasms
- Malignant Neoplasm Of Prostate
- Hyperalgesia
- Neuralgia
- Prostatic Neoplasms
- Neoplasms
- Inflammation
- Nervousness
- Cold Intolerance
- Nerve Damage
- Chronic Pain
Pathways
- Hypersensitivity
- Sensitization
- Reflex
- Localization
- Secretion
- Cell Cycle
- Cell Proliferation
- Pathogenesis
- Response To Cold
- Cell Death
- Micturition
- Membrane Depolarization
- Cell Cycle Arrest
PTMs
- Phosphorylation
- Glycosylation
- Reduction
- Farnesylation
- Myristoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPM8
bosterbio.com/bosterbio-gene-info-cards/TRPM8
References
PMID: 11325849 by Tsavaler L., et al. Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.
PMID: 16174775 by Thebault S., et al. Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store- operated channels in LNCaP human prostate cancer epithelial cells.