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- Table of Contents
Hamartin Antibodies
AND TSC1 ELISA kits, Hamartin Proteins
Many biological assays use antibodies to detect Hamartin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hamartin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hamartin antibodies...
Designing a Western blot for Hamartin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TSC1 Western Blot GuideDesigning an IHC experiment for Hamartin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TSC1 IHC GuideTSC1 Infographic by Boster Bio
All TSC1 Products
Product
Figures
Specificity
Applications
Price
Anti-Hamartin/TSC1 Antibody Picoband®
1 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PA2012
100 μg/vial
Cat # PA2012
100 μg/vial
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00365-2
100 µg/vial
Cat # A00365-2
100 µg/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00365-1
100 μl/vial
Cat # M00365-1
100 μl/vial
TSC1 Overview
Facts about Hamartin.
Hamartin (TSC1)
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Seems not to be needed for TSC2 GAP activity towards RHEB (PubMed:15340059).
Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this appears to be due to unregulated mTOR signaling (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | TSC1 |
| Uniprot: | Q92574 |
| Entrez: | 7248 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Hamartin; KIAA0243MGC86987; LAMhamartin; TSC; TSC1; Tuberous sclerosis 1 protein; tuberous sclerosis 1; tumor suppressor
Molecular Weight
Mass (kDA):
129.767 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.13 |
| Sequence: | 9; NC_000009.12 (132891349..132945269, complement) |
Tissue Specificity
Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells.
Subcellular Localizations
Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.
Diseases
- Tuberous Sclerosis
- Sclerosis
- Neoplasms
- Hamartoma
- Malignant Neoplasms
- Epilepsy
- Hereditary Diseases
- Angiomyolipoma
- Lymphangioleiomyomatosis
- Kidney Neoplasm
- Carcinoma
- Autistic Disorder
Interacting Proteins
- BEX3
- IKBKB
- MAPK14
- TSC2
Pathways
- Cell Growth
- Pathogenesis
- Cell Cycle
- Translation
- Cell Proliferation
- Localization
- Autophagy
- Cell Death
- Brain Development
- Angiogenesis
- Methylation
- Cell Differentiation
- Transport
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
- Farnesylation
- Dephosphorylation
Research Areas
- Cancer
- mTOR Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSC1
bosterbio.com/bosterbio-gene-info-cards/TSC1
References
PMID: 9242607 by van Slegtenhorst M.A., et al. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.
PMID: 9809973 by Plank T.L., et al. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles.