Hamartin Antibodies

AND TSC1 ELISA kits, Hamartin Proteins

Many biological assays use antibodies to detect Hamartin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hamartin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hamartin antibodies...

We validate the specificity of these antibodies to Hamartin by testing them on tissues known to express TSC1 positively and negatively. Browse below to find the TSC1 antibody that suites your experiment. We have 8 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TSC1 Infographic by Boster Bio

All TSC1 Products

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Specificity

Applications

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Anti-Hamartin/TSC1 Antibody Picoband®

1 Citations 5 Q&As

Anti-Hamartin antibody, PA2012, Western blottingAll lanes: Anti Hamartin (PA2012) at 0

Anti-Hamartin antibody, PA2012, IHC(P)IHC(P): Human Mammary Cancer Tissue

Anti-Hamartin antibody, PA2012, IHC(P)IHC(P): Rat Brain Tissue

Human, Mouse, Rat

IHC, WB

$370
Cat # PA2012
100 μg/vial

Anti-Hamartin/TSC1 Antibody Picoband®

1 Citations 16 Q&As

Western blot analysis of Hamartin using anti-Hamartin antibody (PB9120)

Human, Rat

$370
Cat # PB9120
100 μg/vial

Anti-Hamartin TSC1 Antibody

Western blot analysis of TSC1 in EL4 cell lysate with TSC1 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide

Immunocytochemistry of TSC1 in EL4 cells with TSC1 antibody at 2 μg/mL

Immunofluorescence of TSC1 in L1210 cells with TSC1 antibody at 10 μg/mL

Human, Mouse, Rat

ELISA, IF, ICC, WB

$481
Cat # A00365
0.1 mg

Anti-Hamartin TSC1 Antibody

Western blot analysis of extracts of Rat spleen, using TSC1 antibody at 1:1000 dilution

Immunohistochemistry of paraffin-embedded rat pancreatic islet using TSC1 antibody at dilution of 1:200

Immunohistochemistry of paraffin-embedded human gastric cancer using TSC1 antibody at dilution of 1:200

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A00365-1
100ul

Anti-Hamartin (TSC1) Mouse Monoclonal Antibody [Clone ID: OTI3A2]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TSC1 (Right lane) cDNA for 48 hrs and lysed

Western blot analysis of extracts (10ug) from 2 different cell lines by using anti-TSC1 monoclonal antibody at 1:200 dilution

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-TSC1 mouse monoclonal antibody

Human, Mouse, Rat

IHC, WB

$523
Cat # M00365
100 µl

Anti-Hamartin Rabbit Monoclonal Antibody

Western blot analysis of Hamartin expression in HeLa cell lysate

Human

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00365-1
100 μl/vial

Hamartin (TSC1) (NM_000368) Human Over-expression Lysate

Human

$960
Cat # LS007248
20 µg, 100 µg

Anti-Hamartin/TSC1 Antibody Picoband®

Western blot analysis of Hamartin/TSC1 using anti-Hamartin/TSC1 antibody (A00365-2)

IHC analysis of Hamartin/TSC1 using anti-Hamartin/TSC1 antibody (A00365-2)

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00365-2
100 µg/vial

TSC1 Overview

Facts about Hamartin.

TSC1 3D structure. Source: alphafold

Hamartin (TSC1)

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Seems not to be needed for TSC2 GAP activity towards RHEB (PubMed:15340059).

Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this appears to be due to unregulated mTOR signaling (By similarity).

Gene Information

Human
Gene Name:	TSC1
Uniprot:	Q92574
Entrez:	7248

Family

Belongs to:

No superfamily

Alternative Names

Hamartin; KIAA0243MGC86987; LAMhamartin; TSC; TSC1; Tuberous sclerosis 1 protein; tuberous sclerosis 1; tumor suppressor

Molecular Weight

Mass (kDA):
129.767 kDA

Genomic Context


Human

Location:	9q34.13
Sequence:	9; NC_000009.12 (132891349..132945269, complement)

Tissue Specificity

Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells.

Subcellular Localizations

Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.

Diseases

Tuberous Sclerosis
Sclerosis
Neoplasms
Hamartoma
Malignant Neoplasms
Epilepsy
Hereditary Diseases
Angiomyolipoma
Lymphangioleiomyomatosis
Kidney Neoplasm
Carcinoma
Autistic Disorder

Benign Neoplasm
Cell Transformation, Neoplastic
Astrocytoma
Renal Cell Carcinoma
Nervousness
Dysplasia

Interacting Proteins

BEX3
IKBKB
MAPK14
TSC2

Pathways

Cell Growth
Pathogenesis
Cell Cycle
Translation
Cell Proliferation
Localization
Autophagy
Cell Death
Brain Development
Angiogenesis
Methylation
Cell Differentiation
Transport

Hyperphosphorylation
Cell Adhesion
Aging
Dna Repair
Energy Homeostasis
Response To Hypoxia
Regulation Of Cell Size

PTMs

Phosphorylation
Methylation
Ubiquitination
Farnesylation
Dephosphorylation

Cleavage
Acetylation
Geranylgeranylation
Acylation
Ribosylation

Myristoylation

Research Areas

Cancer
mTOR Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSC1

References

PMID: 9242607 by van Slegtenhorst M.A., et al. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.

PMID: 9809973 by Plank T.L., et al. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles.