TSPYL5 Antibodies

AND TSPYL5 ELISA kits, TSPYL5 Proteins

Many biological assays use antibodies to detect TSPYL5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TSPYL5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TSPYL5 antibodies...

We validate the specificity of these antibodies to TSPYL5 by testing them on tissues known to express TSPYL5 positively and negatively. Browse below to find the TSPYL5 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TSPYL5 Infographic by Boster Bio

All TSPYL5 Products

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Specificity

Applications

Price

TSPYL5 (NM_033512) Human Recombinant Protein

Coomassie blue staining of purified TSPYL5 protein

$1249
Cat # PROTQ86VY4
20 µg

TSPYL5 (NM_033512) Human Over-expression Lysate

Human

$628
Cat # LS085453
20 µg, 100 µg

Anti-TSPYL5 Antibody Picoband®

Western blot analysis of TSPYL5 using anti-TSPYL5 antibody (A10648-2)

Flow Cytometry analysis of MCF-7 cells using anti-TSPYL5 antibody (A10648-2)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A10648-2
100 μg/vial

TSPYL5 Overview

Facts about Testis-specific Y-encoded-like protein 5.

TSPYL5 3D structure. Source: alphafold

Testis-specific Y-encoded-like protein 5 (TSPYL5)

Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53.

Suppresses p53/TP53 protein levels and boosts its own ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.

Gene Information

Human
Gene Name:	TSPYL5
Uniprot:	Q86VY4
Entrez:	85453

Family

Belongs to:

nucleosome assembly protein (NAP) family

Alternative Names

KIAA1750; testis-specific Y-encoded-like protein 5; TSPY-like 5; TSPY-like protein 5

Molecular Weight

Mass (kDA):
45.143 kDA

Genomic Context


Human

Location:	8q22.1
Sequence:	8; NC_000008.11 (97273488..97277928, complement)

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Neoplasm Metastasis
Glioma
Malignant Neoplasm Of Lung
Adenocarcinoma
Cell Transformation, Neoplastic
Malignant Squamous Cell Neoplasm
Lung Neoplasms
Glioblastoma
Carcinoma, Transitional Cell
Stomach Neoplasms

Metastatic Malignant Neoplasm To The Lung
Metastatic Squamous Cell Carcinoma
Malignant Neoplasm Of Breast
Head And Neck Carcinoma
Head And Neck Neoplasms
Nervousness
Second Primary Malignancy

Interacting Proteins

USP7

Pathways

Methylation
Dna Methylation
Histone Deacetylation
Gene Silencing
Cell Growth
Senescence
Sensitization
Dna Hypermethylation

Telomere Maintenance
Oncogene-induced Senescence
Oncogenesis

PTMs

Methylation

Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSPYL5

References

PMID: 20079711 by Kim E.J., et al. TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway.

PMID: 21170034 by Epping M.T., et al. TSPYL5 suppresses p53 levels and function by physical interaction with USP7.