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- Table of Contents
UBA1 Antibodies
AND UBA1 ELISA kits, UBA1 Proteins
Many biological assays use antibodies to detect UBA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UBA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UBA1 antibodies...
Designing a Western blot for UBA1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the UBA1 Western Blot GuideDesigning an IHC experiment for UBA1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the UBA1 IHC GuideUBA1 Infographic by Boster Bio
All UBA1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02810
100 μl
Cat # M02810
100 μl
Human, Mouse, Rat
WB
$370
Cat # PB9904
100 μg/vial
Cat # PB9904
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02810-2
100 μl/vial
Cat # M02810-2
100 μl/vial
UBA1 Overview
Facts about Ubiquitin-like modifier-activating enzyme 1.
Ubiquitin-like modifier-activating enzyme 1 (UBA1)
Catalyzes the first step in ubiquitin conjugation to indicate cellular proteins for degradation through the ubiquitin- proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and then linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181).
Essential for the formation of radiation- induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 in DNA damage sites (PubMed:22456334).
Gene Information
| Human | |
|---|---|
| Gene Name: | UBA1 |
| Uniprot: | P22314 |
| Entrez: | 7317 |
Family
| Belongs to: |
|---|
| ubiquitin-activating E1 family |
Alternative Names
A1S9T and BN75 temperature sensitivity complementing; A1S9T; A1ST; AMCX1; GXP1; MGC4781; POC20 centriolar protein homolog; POC20; Protein A1S9; SMAX2; UBA1; UBA1, ubiquitin-activating enzyme E1 homolog A; UBA1A; UBE1; UBE1A1S9; UBE1X; ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivitycomplementing); Ubiquitin-activating enzyme E1; Ubiquitinactivating Enzyme; Ubiquitin-activating Enzyme; ubiquitin-like modifier activating enzyme 1; ubiquitin-like modifier-activating enzyme 1
Molecular Weight
Mass (kDA):
117.849 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.3 |
| Sequence: | X; NC_000023.11 (47190847..47215128) |
Tissue Specificity
Detected in erythrocytes (at protein level). Ubiquitous.
Subcellular Localizations
Cytoplasm. Mitochondrion. Nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Carcinogenesis
- Xeroderma Pigmentosum, Complementation Group C
- Malignant Neoplasm Of Breast
- Neurodegenerative Disorders
- Glioma
- Malignant Tumor Of Cervix
- Malignant Neoplasm Of Lung
- Leukemia, Myelocytic, Acute
- Multiple Myeloma
Interacting Proteins
- GAN
- UBE2I
Pathways
- Conjugation
- Cell Cycle
- Protein Ubiquitination
- Cell Division
- Dna Repair
- Proteolysis
- Cell Cycle Arrest
- Translation
- Localization
- Cell Death
- Pathogenesis
- Autophagy
- Transport
PTMs
- Ubiquitination
- Sumoylation
- Phosphorylation
- Oxidation
Research Areas
- Cell Biology
- Cell Cycle and Replication
- Chromatin Research
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UBA1
bosterbio.com/bosterbio-gene-info-cards/UBA1
References
PMID: 1606621 by Ayusawa D., et al. Complementation by a cloned human ubiquitin-activating enzyme E1 of the S-phase-arrested mouse FM3A cell mutant with thermolabile E1.
PMID: 1986373 by Handley P.M., et al. Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.