Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5)

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome.

Putative regulatory part of the INO80 complex; nonetheless is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome through ADRM1. .