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- Table of Contents
UCHL5 Antibodies
AND UCHL5 ELISA kits, UCHL5 Proteins
Many biological assays use antibodies to detect UCHL5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UCHL5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UCHL5 antibodies...
Designing a Western blot for UCHL5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the UCHL5 Western Blot GuideUCHL5 Infographic by Boster Bio
All UCHL5 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A12338-1
100 µg/vial
Cat # A12338-1
100 µg/vial
Enzyme Activity, SDS-PAGE
$250
Cat # PROTQ9Y5K5
Starting from 20ug
Cat # PROTQ9Y5K5
Starting from 20ug
UCHL5 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase isozyme L5.
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5)
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome.
Putative regulatory part of the INO80 complex; nonetheless is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome through ADRM1. .
Gene Information
| Human | |
|---|---|
| Gene Name: | UCHL5 |
| Uniprot: | Q9Y5K5 |
| Entrez: | 51377 |
Family
| Belongs to: |
|---|
| peptidase C12 family |
Alternative Names
CGI-70; EC 3.4.19.12; INO80 complex subunit R; INO80R; ubiquitin carboxyl-terminal esterase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5; Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5; UCH37; UCH37CGI-70; UCHL5; UCH-L5
Molecular Weight
Mass (kDA):
37.607 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q31.2 |
| Sequence: | 1; NC_000001.11 (193012254..193060140, complement) |
Subcellular Localizations
Cytoplasm. Nucleus. Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Multiple Myeloma
- Cell Transformation, Neoplastic
- Malignant Squamous Cell Neoplasm
- Solid Tumor
- Fanconi Anemia
- Endocrine Gland Neoplasms
- Adenoma
- Neoplasm Metastasis
- Tumor Progression
- Uterine Cervical Neoplasm
Interacting Proteins
- ACTR8
- ADRM1
- INO80E
- NFRKB
- PSMA6
- PSMD2
- PSMD4
- TFPT
- ZBED1
Pathways
- Proteolysis
- Dna Repair
- Conjugation
- Oncogenesis
- Immune Response
- Endocytosis
- Localization
- Methylation
- Nucleus Localization
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UCHL5
bosterbio.com/bosterbio-gene-info-cards/UCHL5
References
PMID: 16906146 by Yao T., et al. Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.
PMID: 16990800 by Hamazaki J., et al. A novel proteasome-interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.