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- Table of Contents

Facts about Ubiquitin carboxyl-terminal hydrolase isozyme L5.
Putative regulatory part of the INO80 complex; nonetheless is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome through ADRM1. .
| Human | |
|---|---|
| Gene Name: | UCHL5 |
| Uniprot: | Q9Y5K5 |
| Entrez: | 51377 |

| Belongs to: |
|---|
| peptidase C12 family |

CGI-70; EC 3.4.19.12; INO80 complex subunit R; INO80R; ubiquitin carboxyl-terminal esterase L5; ubiquitin carboxyl-terminal hydrolase isozyme L5; ubiquitin carboxyl-terminal hydrolase L5; Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5; UCH37; UCH37CGI-70; UCHL5; UCH-L5
Mass (kDA):
37.607 kDA

| Human | |
|---|---|
| Location: | 1q31.2 |
| Sequence: | 1; NC_000001.11 (193012254..193060140, complement) |
Cytoplasm. Nucleus. Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.





PMID: 16906146 by Yao T., et al. Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.
PMID: 16990800 by Hamazaki J., et al. A novel proteasome-interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.