Urocortin-3 Antibodies

Urocortin-3 (Ucn3)

Suppresses food ingestion, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity).

. .

Gene Information

Mouse
Gene Name:	Ucn3
Uniprot:	Q924A4
Entrez:	83428

Family

Belongs to:
sauvagine/corticotropin-releasing factor/urotensin I family

Alternative Names

MGC119002; SPCSCP; stresscopin; Ucn III; UCNIII; urocortin 3 (stresscopin); Urocortin III; urocortin-3

Molecular Weight

Mass (kDA):
18.063 kDA

Genomic Context

Mouse
Location:	13|13 A1
Sequence:	13;

Tissue Specificity

Expressed in some areas of the brain including the hypothalamus, amygdala, and brainstem, but is not evident in the cerebellum, pituitary, or cerebral cortex; it is also expressed peripherally in small intestine and skin.

Diseases

• Nervousness
• Obesity
• Inflammation
• Adenoma
• Neoplasms
• Pituitary Diseases
• Stress, Psychological
• Disease Of Adrenal Medulla
• Hypoxia
• Carcinoma
• Pheochromocytoma
• Hypoglycemia

• Anxiety Disorders
• Adrenal Gland Neoplasms
• Heart Failure
• Physiological Stress
• Hypertrophy
• Depressive Disorder
• Reperfusion Injury

Pathways

• Secretion
• Localization
• Gastric Emptying
• Reverse Transcription
• Feeding Behavior
• Parturition
• Pathogenesis
• Progesterone Secretion
• Fertilization
• Diuresis
• Inflammatory Response
• Sensitization
• Estrus

• Hormone Secretion
• Luteolysis
• Response To Stress
• Synaptic Transmission
• Ovulation
• Energy Homeostasis
• Decidualization

PTMs

• Phosphorylation

• Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ucn3

Boster Bio - Best Uses Of The UCN3 Marker

Boster's primary antibodies might be of interest to anyone who is interested in using the marker-assisted breeder or performing other experiments with the marker. Specifically, the company offers high-affinity primary antibodies that have been validated in Western Blotting, Immunohistochemistry, and ELISA. Boster's antibodies are highly recommended. However, the UCN3 marker is even more powerful.

Boster has high-affinity prima antibodies

If you're looking for a specific antibody against the UCN3 marker, you should consider choosing a high-affinity primary antibody produced by Boster Bio. Boster antibodies have been well-validated in Western Blotting, Immunohistochemistry, and ELISA, which means they're trusted by researchers worldwide. To ensure maximum sensitivity and highest quality, Boster Bio's antibodies have been tested in these formats.

These antibodies are capable of detecting the protein UCN3 from a variety if samples. The company also offers high affinity primary antibodies against UCN3 for your research. The UCN3 marker could be useful for studies that examine aging and cardiovascular disease. This marker could be useful in studying the aging process of diabetics, who are more likely than those not diagnosed with diabetes to be older.

UCN3 expression can be used to identify senescent beta-cells. UCN3 expression in mice was detectable at E17.5 and decreased as diabetes progressed. Its return during the disease process has been used to demonstrate that beta cells can undergo re-differentiation if they lack UCN3.

UCN3 is a member of the CRF family and binds the G-protein coupled receptor CRFR2. Soon after its discovery, beta cells were able to identify its expression. It co-secretes insulin when it is exposed to high glucose levels. It stimulates the secretion and co-secretion of insulin by delta cells. These are the primary cells that make up the islet. High potassium levels, high glucose, and forskolin are able to increase the secretion of insulin when these substances are present in the body.

UCN3 levels have been shown to be elevated in obese patients and to be lower in diabetics. This is consistent with the fact that UCN3 proteins can affect crosstalk between the brain's peripheral organs and the brain. Patients with T2D and a higher BMI had elevated UCN3 levels in SAT. However, this was significantly reduced after supervised exercise in both groups. If you're looking for a high-affinity primary antibody against the UCN3 marker, Boster Bio has a product that can meet your research requirements.

Boster has markers available for marker-assisted breeding

MAS is the best way to determine a trait's genetic control. Breeders can use genetic markers for genetic variation identification and to create breeding protocols. Furthermore, the information provided by genetic markers can aid in QTL mapping and approval of marker-trait associations. Breeders can also make new assortments based on this information. The use of marker-assisted breeding is a useful tool for early generation selection and marker assisted backcrossing.

Plant breeders can benefit at any stage in a plant breeding program by using marker-assisted techniques. MAS is most effective during the early generations, when it can help breeders identify undesirable gene combinations and concentrate on high-priority lines in subsequent generations. However, MAS performs best in early generations, where the linkage between marker gene and QTL is not as tight. As a result, the cost of genotyping large numbers of plants can be higher.

Potential uses of the UCN3 Marker

There are many uses for the UCN3 marker in the body. It has been shown, for example, to increase HSP60 or p–ERK mRNA expression when PA treatment is given. UCN3 was also found not to be in a positive correlation with IL6 mRNA expression when PA was administered to both control and PA-treated mice. The UCN3 marker is useful in determining various cellular processes, such as inflammation.

The increased expression of UCN3 is also believed to exert protective effects against metabolic insults. Although the physiological role of UCN3 remains unclear, these beneficial effects may require signal integration between various cell types and cross-talk between adaptive mechanisms. UCN3 signaling mechanisms will need to be studied further to determine its role in the development metabolic diseases. Further research is needed to identify the molecular mechanisms that confer these beneficial effects.

UCN3 expression was increased by overexpression, including p-ERK and CHOP. It also significantly decreased phosphorylation insulin signaling protein proteins like ERK. However, it also had a significant impact on downstream genes such PERK. This has implications for diabetes and cancer research. It is also possible to treat ER Stress and apoptosis.

UCN3 expression increased glucose uptake by preadipocytes/adipocytes. UCN3 + transgenic mice prevented obesity and hyperglycemia from adipose tissue. UCN3 + mice had a higher metabolic resiliency, insulin sensitivity, and glucose homeostasis. Additionally, muscle stimulation with CRFR2 increased glucose uptake by preadipocytes.

UCN3 deregulation in beta cells does not reflect a passive response to the harmful effects associated with glucotoxicity. It may reflect the adaptive capacity of beta cells to deal with the effects of glucose poisoning. Beta cells can produce a brake that blocks the activity of alpha-cells. This effect may disrupt somatostatin-mediated negative feedback in alpha cells. This negative feedback loop may have therapeutic implications.

Although it is still not clear how UCN3 expression occurs in adipose, research has shown that UCN3 overexpression may be beneficial for weight loss and metabolic disorders. Studies have shown that overexpression of UCN3 in 3T3-L1 adipocytes reduced the mRNA expression of heat shock proteins, including HSP60 and HSP72. It also suppressed apoptosis as well as inflammation.