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- Table of Contents
USP14 Antibodies
AND USP14 ELISA kits, USP14 Proteins
Many biological assays use antibodies to detect USP14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP14 antibodies...
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USP14 Infographic by Boster Bio
All USP14 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M03042
100 μl
Cat # M03042
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A03042-3
100 μg/vial
Cat # A03042-3
100 μg/vial
USP14 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 14.
Ubiquitin carboxyl-terminal hydrolase 14 (USP14)
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin in the proteasome.
Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 that's vital for CXCL12-induced cell chemotaxis.
Gene Information
| Human | |
|---|---|
| Gene Name: | USP14 |
| Uniprot: | P54578 |
| Entrez: | 9097 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 14; EC 3.1.2.15; EC 3.4.19.12; TGT; TGTubiquitin carboxyl-terminal hydrolase 14; tRNA-guanine transglycosylase, 60-kD subunit; ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); ubiquitin specific protease 14 (tRNA-guanine transglycosylase); Ubiquitin Thioesterase 14; Ubiquitin thiolesterase 14; ubiquitin-specific processing protease 14; Ubiquitin-specific-processing protease 14; Ubp6; USP14
Molecular Weight
Mass (kDA):
56.069 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18p11.32 |
| Sequence: | 18; NC_000018.10 (158557..214629) |
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein.
Diseases
- Ataxia
- Malignant Neoplasms
- Nervousness
- Neoplasms
- Neurodegenerative Disorders
- Nervous System Disorder
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lymph Node
- Ovarian Neoplasm
- Solid Tumor
- Severe Acute Respiratory Syndrome
- Chromosome Inversion
Interacting Proteins
- PPP3CA
Pathways
- Conjugation
- Proteolysis
- Synaptic Transmission
- Localization
- Pathogenesis
- Aging
- Dna Repair
- Endocytosis
- Cell Differentiation
- Rna Interference
- Transport
- Bioluminescence
- Intracellular Transport
PTMs
- Ubiquitination
Research Areas
- Protein Turnover
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP14
bosterbio.com/bosterbio-gene-info-cards/USP14
References
PMID: 14499622 by Reuter T.Y., et al. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
PMID: 18162577 by Koulich E., et al. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome.