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- Table of Contents

Facts about Ubiquitin carboxyl-terminal hydrolase 3.
May regulate the DNA damage response (DDR) checkpoint via deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
| Human | |
|---|---|
| Gene Name: | USP3 |
| Uniprot: | Q9Y6I4 |
| Entrez: | 9960 |

| Belongs to: |
|---|
| peptidase C19 family |

Deubiquitinating enzyme 3; EC 3.1.2.15; EC 3.4.19.12; MGC129878; MGC129879; SIH003; ubiquitin carboxyl-terminal hydrolase 3; ubiquitin specific peptidase 3; ubiquitin specific protease 3; ubiquitin thioesterase 3; Ubiquitin thiolesterase 3; Ubiquitin-specific-processing protease 3; UBP
Mass (kDA):
58.897 kDA

| Human | |
|---|---|
| Location: | 15q22.31 |
| Sequence: | 15; NC_000015.10 (63504511..63594640) |
Expressed in all tissues examined, with strongest expression in pancreas.
Nucleus. Localizes preferentially with monoubiquitinated H2A to chromatin.




PMID: 10480896 by Sloper-Mould K.E., et al. Characterization and chromosomal localization of USP3, a novel human ubiquitin-specific protease.
PMID: 17980597 by Nicassio F., et al. Human USP3 is a chromatin modifier required for S phase progression and genome stability.