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- Table of Contents
Facts about Probable ubiquitin carboxyl-terminal hydrolase FAF-X.
Essential component of TGF-beta/BMP signaling cascade. Especially deubiquitinates monoubiquitinated SMAD4, opposing the action of E3 ubiquitin-protein ligase TRIM33.
Human | |
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Gene Name: | USP9X |
Uniprot: | Q93008 |
Entrez: | 8239 |
Belongs to: |
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peptidase C19 family |
Deubiquitinating enzyme FAF-X; DFFRX; DFFRXubiquitin specific protease 9, X-linked (fat facets-like, Drosophila); Drosophila fat facets related, X-linked; EC 3.1.2.15; EC 3.4.19.12; FAF; FAM; Fat facets in mammals; fat facets protein related, X-linked; Fat facets protein-related, X-linked; hFAM; probable ubiquitin carboxyl-terminal hydrolase FAF-X; ubiquitin specific peptidase 9, X-linked (fat facets-like, Drosophila); ubiquitin specific peptidase 9, X-linked; ubiquitin thioesterase FAF-X; Ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; Ubiquitin-specific protease
Mass (kDA):
292.28 kDA
Human | |
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Location: | Xp11.4 |
Sequence: | X; NC_000023.11 (41085420..41236579) |
Widely expressed in embryonic and adult tissues.
Cytoplasm. Cell projection, growth cone.
If you're interested in USP9X marker antibodies, you can purchase them from Boster Bio. The Boster Bio Anti-USP9X Antibody, catalog number A02594, reacts with Human, Mouse, and Rat. This antibody is designed for the use of research purposes. The Boster Bio Anti-USP9X Antibody is a great tool for many applications, including immunohistochemistry and cell biology.
USP9X-labeled antibodies are a versatile tool for immunocytochemistry, Western blot, antigen retrieval, and paraffin tissue analysis. These antibodies are useful for research on a variety of target species. Boster Bio's research primary antibodies using the USP9X marker are available as catalog number A02594. These antibodies are highly purified and are guaranteed for one year from the date of receipt.
The protein USP9X is a deubiquitinase in the USP domain family that prevents the degradation of proteins by removing conjugated ubiquitin. USP9X targets beta-catenin, AF-6, and NUAK1. Other important functions of USP9X include protein trafficking, TGF-beta signaling, and tight junction biogenesis in epithelial cells. It also modulates protein kinases involved in cellular energy homeostasis, stress response, and the ubiquitin ligases.
USP9X-labeled antibodies have been designed to inhibit TCR signaling. This marker blocks TCR signaling proteins by inhibiting p65 and NF-kB activity. USP9X is also associated with the nuclear fusion protein IkBa. The USP9X-labeled antibodies inhibit nuclear translocation and reexpression of IkBa.
The USP9X protein interacts with Bcl10 and regulates the assembly of the CBM complex. Its function is essential for T-cell function, as it modulates the formation of the CBM complex. USP9X-labeled antibodies inhibit these pathways, making them useful for research and development. Further research is needed to understand USP9X function and regulation.
The USP9X protein is involved in the regulation of T-cell function and functions as a tumor suppressor. USP9X knockdown antibodies suppress the activity of this protein and inhibit cell division. The results are consistent with those of proliferation analysis. USP9X-deficient CD4+ T cells divide more slowly than controls, as demonstrated by flow cytometry and total cell counts. Additionally, 7-AAD-stained CD4+ T cells did not exhibit any effect on survival, suggesting that USP9X-deficient CD4+ T cells can serve as a tumor suppressor.
In a recent study, USP9X co-immunoprecipitated with Bcl10 and Carma1. Immunoprecipitates of these proteins were analyzed by SDS-PAGE. Primary antibodies derived from B cells are useful for measuring protein levels. To facilitate this, they can be conjugated with fluorescent antibodies and reporter enzymes to perform different measurements.
In addition to their USP9X ELISA kits, Boster Bio also produces research antibodies and ELISA kits. Their antibodies are validated for WB, IHC, and Flow, and reach picogram sensitivity. The company also offers immunological reagents for research and diagnostic purposes through tebu-bio. The USP9X ELISA kit is a convenient choice for researchers who need high-sensitivity biomarker detection at the nanogram level.
The MBS9361165 kit is an easy-to-use microwell, strip-plate ELISA designed for the quantitative detection of USP9X. It works by detecting native USP9X against its target peptides. It can also be used to analyze samples of undiluted body fluids. For more information about Boster Bio USP9X ELISA kits, please contact us.
The Picokine(tm) ELISA kit line is based on innovative immunogen design and high-sensitivity capture antibodies. This proprietary technology dramatically increases the sensitivity and specificity of ELISA kits, enabling them to detect a range of antigens and proteins with unprecedented sensitivity and specificity. Each kit contains sufficient reagents for 96 tests and has undergone extensive validation against various samples.
The kits include a 96-well plate precoated with an anti-human TNF alpha antibody, ST0000-10 lyophilized recombinant human TNF alpha standard (10ng/tubex2), and AR1103 Avidin-Biotin-Peroxidase Complex (ABC) at a dilution of 1:100. The kits also contain sample diluent buffer (30ml), ABC diluent (12ml), and TMB color developing agent and stop solution 10ml.
For a high-sensitivity, picogram-level ELISA kit for USP9X, you can look no further than Boster Bio. This manufacturer of polyclonal antibodies has a diverse portfolio of over 12,000 products. Many of the company's products are validated against a panel of 250 tissues and cell lines. Boster Bio's antibodies are available through tebu-bio.
PICOBAND(tm) chemistry allows you to identify USP9X by measuring the level of the protein's ion affinity to the USP9X receptor. This ELISA kit can detect levels of the USP9X protein in blood or serum samples. PICOBAND(tm) ELISA kits for the USP9X marker are compatible with all reagents.
PMID: 8922996 by Jones M.H., et al. The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.
PMID: 16322459 by Vong Q.P., et al. Chromosome alignment and segregation regulated by ubiquitination of survivin.