USPL1 Antibodies

AND USPL1 ELISA kits, USPL1 Proteins

Many biological assays use antibodies to detect USPL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USPL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USPL1 antibodies...

We validate the specificity of these antibodies to USPL1 by testing them on tissues known to express USPL1 positively and negatively. Browse below to find the USPL1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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USPL1 Infographic by Boster Bio

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USPL1 (NM_005800) Human Over-expression Lysate

Human

$628
Cat # LS010208
20 µg, 100 µg

USPL1 Overview

Facts about SUMO-specific isopeptidase USPL1.

USPL1 3D structure. Source: alphafold

SUMO-specific isopeptidase USPL1 (USPL1)

SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more economically.

Also able to process full-length SUMO proteins to their adult forms (PubMed:22878415). Plays a key role in RNA polymerase-II- mediated snRNA transcription in the Cajal bodies (PubMed:24413172).

Gene Information

Human
Gene Name:	USPL1
Uniprot:	Q5W0Q7
Entrez:	10208

Family

Belongs to:

peptidase C19 family

Alternative Names

bA121O19.1; C13orf22; chromosome 13 open reading frame 22; D13S106; D13S106E; DKFZp781K2286; FLJ32952; highly charged protein; RP11-121O19.1; ubiquitin specific peptidase like 1; ubiquitin-specific peptidase-like protein 1

Molecular Weight

Mass (kDA):
120.44 kDA

Genomic Context


Human

Location:	13q12.3
Sequence:	13; NC_000013.11 (30617859..30660766)

Subcellular Localizations

Nucleus, Cajal body.

Diseases

Cancer Patients And Suicide And Depression
Headache
Neuromuscular Diseases
Muscular Atrophy
Atrophy
Spinal Muscular Atrophy

Interacting Proteins

SUMO1
SUMO2
SUMO3

Pathways

Mrna Splicing
Cell Proliferation
Cell Death
Pathogenesis
Protein Ubiquitination

PTMs

Sumoylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USPL1

References

PMID: 22878415 by Schulz S., et al. Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions.

PMID: 24413172 by Hutten S., et al. A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II.