Vasodilator-stimulated phosphoprotein (VASP)

Ena/VASP proteins are actin-associated proteins involved in a selection of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation.

It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers on the barbed end of growing actin filaments.