VTCN1 Antibodies

AND VTCN1 ELISA kits, VTCN1 Proteins

Many biological assays use antibodies to detect VTCN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VTCN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VTCN1 antibodies...

We validate the specificity of these antibodies to VTCN1 by testing them on tissues known to express VTCN1 positively and negatively. Browse below to find the VTCN1 antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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VTCN1 Infographic by Boster Bio

All VTCN1 Products

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Applications

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Anti-B7H4/VTCN1 Antibody Picoband®

1 Q&As

Western blot analysis of VTCN1 using anti-VTCN1 antibody (A02821-3)

IHC analysis of VTCN1 using anti-VTCN1 antibody (A02821-3)

IF analysis of VTCN1 using anti-VTCN1 antibody (A02821-3)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A02821-3
100 μg/vial

Human B7-H4 Recombinant Protein

SDS-PAGE

$350
Cat # PROTQ7Z7D3
Starting from 10ug

Anti-B7H4 (VTCN1) Mouse Monoclonal Antibody [Clone ID: OTI9E9]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY VTCN1 (Right lane) cDNA for 48 hrs and lysed

Human, Mouse, Rat

$523
Cat # M02821
100 µl

B7H4 (VTCN1) (NM_024626) Human Over-expression Lysate

Human

$628
Cat # LS079679
20 µg, 100 µg

Anti-B7-H4 / VTCN1 Reference Antibody (alsevalimab)

The purity of Anti-B7-H4/VTCN1 Reference Antibody (alsevalimab)is more than 100%

Immobilized human B7 H4 His at 2 &mug/mL can bind Anti-B7-H4/VTCN1 Reference Antibody (alsevalimab)

Cynomolgus monkey, Human, Mouse

ELISA, Flow Cytometry, Functional Assay, Kinetics

$486
Cat # M02821-1
100 μg

Anti-B7-H4 / VTCN1 Reference Antibody (Millennium patent anti-B7-H4)

The purity of Anti-B7-H4/VTCN1 Reference Antibody (Millennium patent anti-B7-H4)is more than 95%

Human

ELISA, Flow Cytometry, Functional Assay, Kinetics

$486
Cat # M02821-2
100 μg

Anti-VTCN1 Antibody (Monoclonal, 32V36)

Human, Mouse, Rat

IF, ICC, WB

$370
Cat # M02821-3
100 μl/vial

VTCN1 Overview

Facts about V-set domain-containing T-cell activation inhibitor 1.

VTCN1 3D structure. Source: alphafold

V-set domain-containing T-cell activation inhibitor 1 (VTCN1)

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an essential role, together with regulatory T-cells (Treg), in the suppression of tumor- related antigen-specific T-cell immunity.

Involved in promoting epithelial cell transformation. .

Gene Information

Human
Gene Name:	VTCN1
Uniprot:	Q7Z7D3
Entrez:	79679

Family

Belongs to:

immunoglobulin superfamily

Alternative Names

B7h.5; B7H4; B7-H4; B7H4T-cell costimulatory molecule B7x; B7S1; B7S1VCTN1; B7x; B7XPRO1291; FLJ22418; Immune costimulatory protein B7-H4; Protein B7S1; T cell costimulatory molecule B7x; V-set domain containing T cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; Vtcn1

Molecular Weight

Mass (kDA):
30.878 kDA

Genomic Context


Human

Location:	1p13.1-p12
Sequence:	1; NC_000001.11 (117143587..117210985, complement)

Tissue Specificity

Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.