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- Table of Contents
VTCN1 Antibodies
AND VTCN1 ELISA kits, VTCN1 Proteins
Many biological assays use antibodies to detect VTCN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VTCN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VTCN1 antibodies...
Designing a Western blot for VTCN1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the VTCN1 Western Blot GuideVTCN1 Infographic by Boster Bio
All VTCN1 Products
Product
Figures
Specificity
Applications
Price
Anti-PPP2R1A Antibody Picoband®
1 Citations
Human, Monkey, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # A02822-2
100 μg/vial
Cat # A02822-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02821-3
100 μg/vial
Cat # A02821-3
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M02821-2
100 μg
Cat # M02821-2
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M02821-1
100 μg
Cat # M02821-1
100 μg
VTCN1 Overview
Facts about V-set domain-containing T-cell activation inhibitor 1.
V-set domain-containing T-cell activation inhibitor 1 (VTCN1)
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an essential role, together with regulatory T-cells (Treg), in the suppression of tumor- related antigen-specific T-cell immunity.
Involved in promoting epithelial cell transformation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | VTCN1 |
| Uniprot: | Q7Z7D3 |
| Entrez: | 79679 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
B7h.5; B7H4; B7-H4; B7H4T-cell costimulatory molecule B7x; B7S1; B7S1VCTN1; B7x; B7XPRO1291; FLJ22418; Immune costimulatory protein B7-H4; Protein B7S1; T cell costimulatory molecule B7x; V-set domain containing T cell activation inhibitor 1; V-set domain-containing T-cell activation inhibitor 1; Vtcn1
Molecular Weight
Mass (kDA):
30.878 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.1-p12 |
| Sequence: | 1; NC_000001.11 (117143587..117210985, complement) |
Tissue Specificity
Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Expressed at the cell surface. A soluble form has also been detected.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Ovarian Neoplasm
- Malignant Neoplasm Of Ovary
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Autoimmune Reaction
- Arthritis
- Tumor Progression
- Malignant Neoplasm Of Breast
- Decreased Immunologic Activity [pe]
- Metastatic Malignant Neoplasm To The Lymph Node
Pathways
- Immune Response
- Cell Proliferation
- Cell Cycle
- Secretion
- T Cell Proliferation
- Cell Activation
- T Cell Activation
- Pathogenesis
- Cytokine Production
- Localization
- Cytokine Secretion
- Cell Cycle Arrest
- Cell Growth
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VTCN1
bosterbio.com/bosterbio-gene-info-cards/VTCN1
References
PMID: 12818165 by Sica G.L., et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
PMID: 12920180 by Zang X., et al. B7x: a widely expressed B7 family member that inhibits T cell activation.