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- Table of Contents
Facts about Neural Wiskott-Aldrich syndrome protein.
Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its function in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080).
Human | |
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Gene Name: | WASL |
Uniprot: | O00401 |
Entrez: | 8976 |
Belongs to: |
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No superfamily |
NWASP; N-WASP; N-WASPneural WiskNWASP; TRS4; WASL; WiskDKFZp779G0847; WiskMGC48327
Mass (kDA):
54.827 kDA
Human | |
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Location: | 7q31.32 |
Sequence: | 7; NC_000007.14 (123681943..123749003, complement) |
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (By similarity).
Steven Boster, PhD, is a leading researcher in the area of skin cancer. Read about 10 recent publications and his research interests in this Research Spotlight. Discover more about Boster's research. He has also published several books and articles. The WASL marker has been used to target tumors and improve clinical outcomes in cancer patients. Boster scientists have also developed a self-powered smart patch that can serve as a reservoir for chemokine/neurodirecting exosomes and stimulate skin neuro-engineering and tissue regeneration.
Dr. Boster is a board-certified neurologist and an expert in the treatment of multiple sclerosis. After graduating from Oberlin College and the University of Cincinnati College of Medicine, he completed his neurology residency at the University of Michigan Hospital Systems and his fellowship in clinical neuroimmunology and multiple sclerosis at Wayne State University in Detroit. During his training, Dr. Boster studied the effects of intense immunosuppression on the immune system in people with multiple sclerosis. His research interests have been widely published and he has presented at several national and international meetings.
While Steven Boster's first product was a series of primary antibodies used in IHC, his success in the early nineties eventually led to the creation of an entire catalog antibody company in China. He also developed a proprietary ELISA platform, PicoKine(tm), which delivers high-sensitivity ELISA kits. As a result, Boster has been called the "science guy" by many of his colleagues.
PMID: 9322739 by Fukuoka M., et al. Identification of N-WASP homologs in human and rat brain.
PMID: 9422512 by Miki H., et al. Induction of filopodium formation by a WASP-related actin- depolymerizing protein N-WASP.