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- Table of Contents
WASL Antibodies
AND WASL ELISA kits, WASL Proteins
Many biological assays use antibodies to detect WASL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WASL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WASL antibodies...
Designing a Western blot for WASL? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the WASL Western Blot GuideWASL Infographic by Boster Bio
All WASL Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A05438-3
100 μg/vial
Cat # A05438-3
100 μg/vial
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M05438
100 μl
Cat # M05438
100 μl
WASL Overview
Facts about Neural Wiskott-Aldrich syndrome protein.
Neural Wiskott-Aldrich syndrome protein (WASL)
Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex (PubMed:9422512, PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828). Involved in a variety of processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:9422512, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828).
Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512). In addition to its function in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080).
Gene Information
| Human | |
|---|---|
| Gene Name: | WASL |
| Uniprot: | O00401 |
| Entrez: | 8976 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
NWASP; N-WASP; N-WASPneural WiskNWASP; TRS4; WASL; WiskDKFZp779G0847; WiskMGC48327
Molecular Weight
Mass (kDA):
54.827 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q31.32 |
| Sequence: | 7; NC_000007.14 (123681943..123749003, complement) |
Subcellular Localizations
Cytoplasm, cytoskeleton. Nucleus. Cytoplasm. Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (By similarity).
Diseases
- Wiskott-aldrich Syndrome
- Shigella Infections
- Tissue Adhesions
- Malignant Neoplasms
- Cell Invasion
- Protrusion
- Neoplasms
- Vaccinia
- Neoplasm Invasiveness
- Disease Caused By Shigella Flexneri
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Carcinoma
Interacting Proteins
- ARPC3
- CDC42
- CIB1
- Fnbp1
- GRB2
- NCK1
- NCK2
- PTK6
- RHOJ
- RNF8
Pathways
- Actin Nucleation
- Localization
- Endocytosis
- Cell Migration
- Transport
- Cell Motility
- Rna Interference
- Secretion
- Clathrin-mediated Endocytosis
- Cell Adhesion
- Pathogenesis
- Chemotaxis
- Phagocytosis
PTMs
- Phosphorylation
- Cleavage
- Amination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WASL
bosterbio.com/bosterbio-gene-info-cards/WASL
References
PMID: 9322739 by Fukuoka M., et al. Identification of N-WASP homologs in human and rat brain.
PMID: 9422512 by Miki H., et al. Induction of filopodium formation by a WASP-related actin- depolymerizing protein N-WASP.