WDR24 Antibodies

AND WDR24 ELISA kits, WDR24 Proteins

Many biological assays use antibodies to detect WDR24, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR24 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR24 antibodies...

We validate the specificity of these antibodies to WDR24 by testing them on tissues known to express WDR24 positively and negatively. Browse below to find the WDR24 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WDR24 Infographic by Boster Bio

All WDR24 Products

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WDR24 (NM_032259) Human Over-expression Lysate

Human

$628
Cat # LS084219
20 µg, 100 µg

Anti-WDR24 Antibody Picoband®

Western blot analysis of WDR24 using anti-WDR24 antibody (A12216)

Human, Mouse, Rat

ELISA, WB

$370
Cat # A12216
100 µg/vial

WDR24 Overview

Facts about GATOR complex protein WDR24.

WDR24 3D structure. Source: alphafold

GATOR complex protein WDR24 (WDR24)

As a part of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of this TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).

It's negatively regulated by the upstream amino acid detectors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of this TORC1 complicated, promotes the acidification of lysosomes and eases autophagic flux (PubMed:27166823).

Gene Information

Human
Gene Name:	WDR24
Uniprot:	Q96S15
Entrez:	84219

Family

Belongs to:

WD repeat WDR24 family

Alternative Names

GATOR complex protein WDR24

Molecular Weight

Mass (kDA):
88.207 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (684622..690661, complement)

Subcellular Localizations

Lysosome membrane.

Interacting Proteins

APPBP2
MIOS
SESN2
SESN3
SZT2

WDR59

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR24

References

PMID: 25263562 by Chantranupong L., et al. The Sestrins interact with GATOR2 to negatively regulate the amino- acid-sensing pathway upstream of mTORC1.

PMID: 25457612 by Parmigiani A., et al. Sestrins inhibit mTORC1 kinase activation through the GATOR complex.