YOD1 Antibodies

AND YOD1 ELISA kits, YOD1 Proteins

Many biological assays use antibodies to detect YOD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with YOD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop YOD1 antibodies...

We validate the specificity of these antibodies to YOD1 by testing them on tissues known to express YOD1 positively and negatively. Browse below to find the YOD1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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YOD1 Infographic by Boster Bio

All YOD1 Products

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Product

Figures

Specificity

Applications

Price

Human YOD1 Recombinant Protein

SDS-PAGE

$275
Cat # PROTQ5VVQ6
Starting from 10ug

YOD1 (NM_018566) Human Over-expression Lysate

Human

$628
Cat # LS055432
20 µg, 100 µg

Anti-YOD1 Antibody

Human

ELISA, IHC, WB

$370
Cat # A09885-2
100 μl/vial

YOD1 Overview

Facts about Ubiquitin thioesterase OTU1.

YOD1 3D structure. Source: alphafold

Ubiquitin thioesterase OTU1 (YOD1)

Hydrolase that may remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore.

Ubiquitin moieties on substrates may present a steric impediment to the threading procedure once the substrate is moved to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains.

Gene Information

Human
Gene Name:	YOD1
Uniprot:	Q5VVQ6
Entrez:	55432

Family

Belongs to:

No superfamily

Alternative Names

DKFZp451J1719; DUBA8; DUBA-8; DUBA8hsHIN7; EC 3.1.2; EC 3.4.19.12; HIN7; HIN-7; HIV-1-induced protease 7; HsHIN7; OTU domain-containing protein 2; OTUD2; OTUD2OTU domain containing 2; PRO0907; ubiquitin thioesterase OTU1; YOD1 OTU deubiquinating enzyme 1 homolog ( yeast); YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae); YOD1

Molecular Weight

Mass (kDA):
38.322 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (207043849..207052980, complement)

Subcellular Localizations

Cytoplasm. Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains.

Diseases

Dislocations
Cystic Fibrosis
Right Ventricular Hypertrophy
Proteostasis Deficiencies
Hypoxia
Lung Diseases
Hypertensive Disease
Hypertrophy
Neoplasms

Cytomegalovirus Infections
Pulmonary Hypertension
Ovarian Neoplasm
Anoxia

Pathways

Transport
Cell Proliferation
Pathogenesis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/YOD1

References

PMID: 11483580 by Yu Y., et al. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.

PMID: 19818707 by Ernst R., et al. The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.