Ubiquitin thioesterase OTU1 (YOD1)

Hydrolase that may remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore.

Ubiquitin moieties on substrates may present a steric impediment to the threading procedure once the substrate is moved to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains.