ZBTB1 Antibodies

AND ZBTB1 ELISA kits, ZBTB1 Proteins

Many biological assays use antibodies to detect ZBTB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZBTB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZBTB1 antibodies...

We validate the specificity of these antibodies to ZBTB1 by testing them on tissues known to express ZBTB1 positively and negatively. Browse below to find the ZBTB1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZBTB1 Infographic by Boster Bio

All ZBTB1 Products

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Anti-ZBTB1 Antibody

Western blot analysis of ZBTB1 in HepG2 lysate with ZBTB1 antibody at (A) 1 and (B) 2 μg/mL

Immunohistochemistry of ZBTB1 in mouse brain tissue with ZBTB1 antibody at 2

Human, Mouse, Rat

ELISA, IHC-P, WB

$481
Cat # A09282
0.1 mg

ZBTB1 (NM_014950) Human Over-expression Lysate

Human

$960
Cat # LS022890
20 µg, 100 µg

Anti-ZBTB1 Antibody

Human

ELISA, IP, IF, ICC, WB

$370
Cat # A09282-1
100 μl/vial

ZBTB1 Overview

Facts about Zinc finger and BTB domain-containing protein 1.

ZBTB1 3D structure. Source: alphafold

Zinc finger and BTB domain-containing protein 1 (ZBTB1)

Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167).

Additionally, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruiting to replication factories and efficient translesion DNA synthesis (PubMed:24657165).

Gene Information

Human
Gene Name:	ZBTB1
Uniprot:	Q9Y2K1
Entrez:	22890

Family

Belongs to:

No superfamily

Alternative Names

zinc finger and BTB domain containing 1

Molecular Weight

Mass (kDA):
82.016 kDA

Genomic Context


Human

Location:	14q23.3
Sequence:	14; NC_000014.9 (64504574..64533693)

Subcellular Localizations

Nucleus. Nucleus, nucleoplasm. Localized in dot-like structures in the nucleus (PubMed:21706167). Colocalized with SMRT in nuclear bodies (PubMed:20797634). The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies(PubMed:20797634).

Diseases

Immunologic Deficiency Syndromes
T-lymphocyte Deficiency
Severe Combined Immunodeficiency
Lymphopenia
Inflammation
Inflammatory Response

Interacting Proteins

FAM161A
PIM1
TRIM42
ZNF417
ZNF572

Pathways

Cell Development
Cell Proliferation
Isotype Switching
Cell Differentiation
Pathogenesis
Localization
Conjugation

Inflammatory Response

PTMs

Sumoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZBTB1

References

PMID: 20797634 by Matic I., et al. Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.

PMID: 21706167 by Liu Q., et al. Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE.