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B-cells (or B lymphocytes) are a category of white blood cells that express clonally diverse B-cell receptors (BCRs) which recognize specific antigenic epitopes. B lymphocytes also play a critical role in the adaptive humoral immune system by producing and secreting antigen-specific immunoglobulin (Ig) (generally referred as antibodies). Development of B-cells begins with the differentiation of hematopoietic stem cells (HSCs) located in the fetal liver and bone marrow that ultimately give rise to the B-cell lineage. Each stage of B-cell development is mainly characterized by the expression and rearrangement of BCR components.
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