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Premium Custom Peptide Synthesis Services

High-Quality Peptides, Delivered Fast

Leading custom peptide synthesis company in the USA with >95% success rate, competitive pricing, and comprehensive quality control.

  • ✓ 99% Success Rate - Industry-Leading Quality
  • ✓ 5-15 Business Days Delivery
  • ✓ ISO 9001 Certified Facility
  • ✓ Free Technical Consultation
  • ✓ No-Risk, No-Fee Guarantee

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Custom Peptide Synthesis Services

From research-grade peptides to large-scale manufacturing, we provide comprehensive custom peptide synthesis solutions with guaranteed quality and competitive pricing.

Standard Peptides

2-60 amino acids with purities from crude to >98%. Perfect for research applications, antibody production, and bioassays. Starting at $4.50/AA.

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Modified Peptides

Over 200 modifications available, including phosphorylation, acetylation, biotinylation, PEGylation, fluorescent labels, and more.

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Complex Sequences

Long peptides (60-120 AA), difficult sequences, multiple disulfide bonds, and cyclic peptides are synthesized with advanced techniques.

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Why We're Among the Top Peptide Companies in the USA

Your trusted partner for custom peptide synthesis services

As one of the most reputable peptide companies, we combine decades of expertise with cutting-edge technology to deliver the highest quality peptides. Our custom peptide synthesis services are trusted by leading research institutions, pharmaceutical companies, and biotechnology firms worldwide.

We understand that every research project is unique. That's why we offer personalized consultations with our expert peptide chemists to help you design and optimize your custom peptides for maximum performance in your specific application.

From simple linear peptides to complex cyclic structures with multiple modifications, our team has successfully synthesized over 100,000 custom peptides with a 99% success rate. We're not just peptide manufacturers – we're your partners in scientific discovery.

Need Custom Peptides Fast?

Express synthesis service available with delivery in as fast as 5 business days. No rush fees for standard modifications!

Request Express Service

Standard Process for Custom Peptide Synthesis

Our proven 7-step process ensures consistent quality and timely delivery of your custom peptides

  • 1. Sequence Analysis & Quote

    Our expert chemists analyze your peptide sequence to identify potential synthesis challenges and provide an accurate quote. Get instant quotes online or request a detailed consultation for complex peptides.

  • 2. Solid Phase Peptide Synthesis (SPPS)

    Using advanced Fmoc or Boc chemistry, we synthesize your peptide using automated synthesizers with real-time monitoring. Each coupling step is verified using UV monitoring and Kaiser tests to ensure >99% completion before proceeding.

  • 3. Cleavage & Deprotection

    The peptide is cleaved from the resin and protecting groups are removed using optimized conditions specific to your peptide's sequence and modifications. Special care is taken to minimize racemization and side reactions.

  • 4. Crude Analysis

    Initial HPLC and MS analysis of crude peptide to verify synthesis success and determine the optimal purification strategy. This step helps us achieve your target purity efficiently.

  • 5. HPLC Purification

    High-performance liquid chromatography (HPLC) purification using optimized gradients and conditions. Multiple purification rounds are needed to achieve your specified purity level (80%, 90%, 95%, or 98%).

  • 6. Quality Control Testing

    Comprehensive QC including analytical HPLC (purity determination), mass spectrometry (identity confirmation), amino acid analysis (quantity verification), and additional tests as specified. Every peptide comes with complete QC documentation.

  • 7. Delivery & Support

    Your peptide is lyophilized, properly packaged, and shipped with cold packs. Includes Certificate of Analysis (CoA), HPLC chromatogram, MS spectrum, and handling/storage instructions. Free technical support is available post-delivery.

Comprehensive Quality Control Measures

Industry-leading quality control ensures you receive the highest quality peptides, every time

Comprehensive Quality Control for Every Custom Peptide

Clear documentation, verified purity, confirmed identity

Quality control is the cornerstone of reliable peptide synthesis. Every custom peptide is tested for purity, identity, and content so you can trust the result in downstream experiments.

Standard QC Included

  • ✓ Analytical HPLC (purity)
  • ✓ Mass Spectrometry (identity)
  • ✓ Peptide content / net peptide weight
  • ✓ CoA + HPLC chromatogram + MS spectrum

Optional Add-ons

  • ✓ Endotoxin testing
  • ✓ Counter ion analysis
  • ✓ Water content (Karl Fischer)
  • ✓ Optical rotation (chiral purity)

Need raw data files or a specific QC package for regulatory or publication requirements? Tell us in the quote form and we’ll tailor the report.

QC Guarantee

No-Risk, No-Fee Policy

If your peptide does not meet the specified purity/identity requirements, we will re-synthesize it at no cost or issue a full refund.

What you receive

  • Certificate of Analysis (CoA)
  • HPLC chromatogram
  • MS spectrum
  • Synthesis report
  • Storage & handling guide
  • Free technical support

Custom Peptide Synthesis Price Guide

Transparent, competitive pricing with no hidden fees

Our custom peptide synthesis prices are based on sequence length, purity level, scale, and modifications. Below are the starting prices for standard peptides.

Purity Level Price per AA (5mg scale) Typical Applications Turnaround Time
Crude (>40%) $3.50/AA Optimization studies, preliminary screening 5-7 days
Immunological Grade (>60%) $4.50/AA Polyclonal antibody production 7-10 days
High Purity (>80%) $6.50/AA Cell culture, Western blot, tissue culture 10-12 days
Very High Purity (>90%) $8.50/AA In vivo studies, bioassays, monoclonal antibodies 12-15 days
Ultra-Pure (>95%) $11.50/AA ELISA, RIA, enzyme studies, SAR studies 15-18 days
Highest Purity (>98%) $15.50/AA NMR, crystallography, reference standards 18-21 days

Volume Discounts: 10-25% off for orders >100mg. Contact us for bulk pricing.

Modifications: Additional charges apply for special modifications, labels, and complex structures. Get detailed quote online.

Wide Range of Peptide Modifications

Over 200 modifications available to customize your peptides

We offer an extensive catalog of peptide modifications to meet your specific research needs. Our expert chemists have years of experience incorporating complex modifications while maintaining peptide integrity.

N-Terminal Modifications

  • • Acetylation (Ac-)
  • • Biotinylation
  • • Fluorescent labels (FITC, FAM, TAMRA, Cy3, Cy5, Cy7)
  • • PEGylation (PEG2-PEG48)
  • • Myristoylation, Palmitoylation
  • • Dansyl, Dabcyl, EDANS
  • • Fmoc, Boc, Z (Cbz)
  • • DOTA, DTPA (for chelation)

Side Chain Modifications

  • • Phosphorylation (Ser, Thr, Tyr)
  • • Methylation, Acetylation
  • • Sulfation
  • • Hydroxylation
  • • Glycosylation
  • • Nitration

C-Terminal Modifications

  • • Amidation (-CONH₂)
  • • Methyl ester (-COOCH₃)
  • • Ethyl ester (-COOC₂H₅)
  • • Aldehyde (-CHO)
  • • Hydroxamic acid
  • • p-Nitroanilide (for enzyme substrates)
  • • AMC, AFC (fluorogenic substrates)

Special Structures

  • • Cyclic peptides (head-to-tail, side chain-to-side chain)
  • • Disulfide bond formation (single or multiple)
  • • Stapled peptides
  • • Branched peptides
  • • D-amino acids incorporation
  • • Unnatural amino acids
  • • Isotope labeling (¹³C, ¹⁵N, ²H)

Diverse Applications We Support

Our custom peptides are used in a wide range of scientific applications

Drug Discovery

Lead optimization, SAR studies, target validation, and peptide therapeutics development for pharmaceutical research.

Antibody Production

Immunogens for polyclonal and monoclonal antibody generation, epitope mapping, and affinity purification.

Diagnostics

ELISA standards, IVD reagents, biomarker discovery, and diagnostic assay development for clinical applications.

Proteomics

Mass spec standards, protein quantification, PTM analysis, and protein-protein interaction studies.

Frequently Asked Questions

Common questions about custom peptide synthesis services

Q1. What is the typical turnaround time for custom peptide synthesis?

Standard peptides (2-30 AA, >80% purity) are typically delivered in 10-15 business days. Express service is available for 5-7 day delivery. Complex peptides with multiple modifications or longer sequences may require 3-4 weeks. An exact timeline will be provided with your quote.

Purity requirements depend on your application: Polyclonal antibody production requires >60% (immunological grade). Cell culture and Western blot studies need >80%. In vivo studies and bioassays require >90%. ELISA, RIA, and enzyme studies need >95%. NMR and crystallography require >98%. Our scientists can help recommend the appropriate purity for your specific needs.

Prices start at $3.50 per amino acid for crude peptides and range up to $15.50/AA for ultra-pure (>98%) peptides at 5mg scale. Costs depend on sequence length, purity level, scale, and modifications. Volume discounts of 10-25% available for orders >100mg. Use our online quote system for instant pricing or contact us for detailed quotes on complex projects.

Every peptide undergoes: (1) Analytical HPLC for purity determination, (2) Mass spectrometry (ESI-MS or MALDI-TOF) for identity confirmation, (3) Amino acid analysis for peptide content verification. Additional tests available include endotoxin testing, counter ion analysis, optical rotation, and peptide content by UV. Complete documentation including CoA, HPLC chromatogram, and MS spectrum provided with every order.

Yes! We specialize in challenging peptides. Our expertise includes: Long peptides up to 120 amino acids, sequences with multiple disulfide bonds, highly hydrophobic sequences, peptides prone to aggregation, cyclic and stapled peptides, and peptides with complex modification patterns. We use advanced techniques like pseudoproline building blocks, microwave-assisted synthesis, and optimized coupling conditions to achieve high success rates even with difficult sequences.

We maintain a 99% success rate for standard peptides (2-60 AA) and >95% for complex/long peptides. Our no-risk, no-fee guarantee means if we cannot synthesize your peptide to specifications, you don't pay. This is backed by our rigorous in-process monitoring, experienced chemists, and quality control protocols.

Yes, we offer both peptide array services and discrete peptide libraries. Services include overlapping peptide libraries for epitope mapping, alanine-scanning libraries, positional-scanning libraries, truncation libraries, and scrambled peptide controls. Special pricing available for libraries with >10 peptides. Contact us for custom library design consultation.

We offer over 200 modifications including: N-terminal modifications (acetylation, biotinylation, fluorescent labels, PEGylation), C-terminal modifications (amidation, esters, aldehydes), side chain modifications (phosphorylation, methylation, acetylation), special structures (cyclization, disulfide bonds, stapling), labels and tags (FITC, TAMRA, Cy dyes, biotin, DOTA), and D-amino acids and unnatural amino acids. If you need a modification not listed, contact us - we can likely accommodate it.

99% Success Rate
Industry-leading synthesis
completion rate

5-15 Days
Fast turnaround time
for standard peptides

Global Reach
Serving 50+ countries
worldwide

ISO 9001
Certified quality
management system

Expert Team
PhD-level scientists
30+ years experience