Anti-Ms CD11a Purified Itgal Monoclonal Antibody

ITGAL antibody

Boster Bio Anti-Ms CD11a Purified Itgal Monoclonal Antibody (Catalog# M04466-2). Tested in Flow Cytometry, IP, IHC-F application(s). This antibody reacts with Mouse.

Product Info Summary

SKU: M04466-2
Size: 0.1 mg
Reactive Species: Mouse
Host: Rat
Application: Flow Cytometry, IP, IHC-F

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Product Name

Anti-Ms CD11a Purified Itgal Monoclonal Antibody

View all ITGAL Antibodies

SKU/Catalog Number

M04466-2

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Ms CD11a Purified Itgal Monoclonal Antibody (Catalog# M04466-2). Tested in Flow Cytometry, IP, IHC-F application(s). This antibody reacts with Mouse.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Ms CD11a Purified Itgal Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M04466-2)

Host

Rat

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

M17/4

Isotype

Rat IgG2a

Immunogen

C57BL/6 mouse splenic secondary cytotoxic T lymphocytes. The rat monoclonal antibody M17/4 reacts with an extracellular epitope of CD11a (alpha-subunit of murine LFA-1), a 180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M04466-2 is reactive to ITGAL in Mouse

Applications

M04466-2 is guaranteed for Flow Cytometry, IP, IHC-F Boster Guarantee

Observed Molecular Weight

19 kDa

Calculated molecular weight

128.77kDa

Background of ITGAL

CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 1 μg/ml.
Immunohistochemistry (frozen sections): Positive tissue: murine spleen or thymus, acetone fixation.

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For ITGAL (Source: Uniprot.org, NCBI)

Gene Name

ITGAL

Full Name

Integrin alpha-L

Weight

128.77kDa

Superfamily

integrin alpha chain family

Alternative Names

CD11 antigen-like family member A; CD11a antigen; CD11a; CD11Aantigen CD11A (p180), lymphocyte function-associated antigen 1, alphapolypeptide; Integrin alpha L; integrin alpha-L; integrin gene promoter; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen1; alpha polypeptide); ITGAL; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA-1 alpha; LFA-1; LFA1A; LFA-1A; Ly-15; Ly-21; lymphocyte function-associated antigen 1 ITGAL CD11A, LFA-1, LFA1A integrin subunit alpha L integrin alpha-L|CD11 antigen-like family member A|LFA-1 alpha|LFA-1A|antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide|integrin gene promoter|integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)|leukocyte adhesion glycoprotein LFA-1 alpha chain|leukocyte function-associated molecule 1 alpha chain|lymphocyte function-associated antigen 1, alpha polypeptide

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ITGAL, check out the ITGAL Infographic

ITGAL infographic

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In this infographic, you will see the following information for ITGAL: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M04466-2

100 µg

$256

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M04466-2
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$256.00

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