Integrin beta-6 Antibodies

AND ITGB6 ELISA kits, Integrin beta-6 Proteins

Many biological assays use antibodies to detect Integrin beta-6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin beta-6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin beta-6 antibodies...

We validate the specificity of these antibodies to Integrin beta-6 by testing them on tissues known to express ITGB6 positively and negatively. Browse below to find the ITGB6 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ITGB6 Infographic by Boster Bio

All ITGB6 Products

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Product

Figures

Specificity

Applications

Price

Anti-ITGB6 Mouse Monoclonal Antibody [Clone ID: OTI1D2]

Human, Mouse, Rat

$523
Cat # M03800
100 µl

ITGB6 (NM_000888) Human Over-expression Lysate

Human

$960
Cat # LS003694
100 µg

ITGB6 Overview

Facts about Integrin beta-6.

ITGB6 3D structure. Source: alphafold

Integrin beta-6 (ITGB6)

Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881).

Internalisation of integrin alpha-V/beta-6 through clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 functions as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881).

Gene Information

Human
Gene Name:	ITGB6
Uniprot:	P18564
Entrez:	3694

Family

Belongs to:

integrin beta chain family

Alternative Names

Integrin beta 6; integrin beta-6; integrin, beta 6; ITGB6

Molecular Weight

Mass (kDA):
85.936 kDA

Genomic Context


Human

Location:	2q24.2
Sequence:	2; NC_000002.12 (160099666..160200313, complement)

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.

Diseases

Pulmonary Emphysema
Neoplasms
Inflammation
Tissue Adhesions
Neoplasm Metastasis
Brain Ischemia
Melanoma
Low Set Ears
Inflammatory Bowel Diseases
Lung Diseases
Intestinal Diseases
Carcinoma
Ulcer

Dysplasia
Injury To Liver
Fibrosis
Tumor Angiogenesis
Cytomegalovirus Infections
Biliary Fibrosis
Dwarfism

Interacting Proteins

ITGAV

Pathways

Cell Growth
Angiogenesis
Cognition
Tropism
Localization

PTMs

Phosphorylation

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGB6

References

PMID: 2365683 by Sheppard D., et al. Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.

PMID: 1382574 by Jiang W.-M., et al. The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.