Anti-P2X purinoceptor 7 P2RX7 Antibody

Product Name

Anti-P2X purinoceptor 7 P2RX7 Antibody

View all P2RX7 Antibodies

SKU/Catalog Number

A01208

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-P2X purinoceptor 7 P2RX7 Antibody (Catalog # A01208). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.

Storage & Handling

P2RX7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Cite This Product

Anti-P2X purinoceptor 7 P2RX7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01208)

Host

Rabbit

Contents

P2RX7 antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

P2RX7 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human P2RX7. The immunogen is located within the last 50 amino acids of P2RX7.

Cross-reactivity

P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.

Reactive Species

A01208 is reactive to P2RX7 in Human, Mouse

Observed Molecular Weight

68 kDa

Calculated molecular weight

68.6 kDa

Background of P2RX7

The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1). This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2). Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2). Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A01208 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

P2RX7 antibody can be used for detection of P2RX7 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information P2RX7

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