Protein kinase C gamma type (PRKCG)

Calcium-activated, phospholipid- and diacylglycerol (DAG)-reliant serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye cells, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of adrenal and adrenal functions related to sensitivity to opiates, alcohol and pain, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by raising plasma membrane-associated GRIA4 expression.

May be involved in the regulation of hippocampal long-term potentiation (LTP), but might be not essential for the practice of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and might be crucial for the development and/or maintenance of morphine-induced reinforcing consequences in the limbic forebrain.