Anti-SIRT3 Antibody

Product Name

Anti-SIRT3 Antibody

View all Sirtuin 3/SIRT3 Antibodies

SKU/Catalog Number

A01061

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-SIRT3 Antibody (Catalog # A01061). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

SIRT3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-SIRT3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01061)

Host

Chicken

Contents

SIRT3 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgY

Immunogen

SIRT3 antibody was raised against a 17 amino acid synthetic peptide near the center of human SIRT3. The immunogen is located within amino acids 180 - 230 of SIRT3.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A01061 is reactive to SIRT3 in Human, Mouse, Rat

Applications

A01061 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

43.573kDa

Background of Sirtuin 3/SIRT3

The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence, lifespan extension and several age-related diseases. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) and SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. It is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2. SIRT3 is stress-responsive and its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

SIRT3 antibody can be used for detection of SIRT3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of SIRT3 in mouse heart tissue lysate with SIRT3 antibody at (A) 1 and (B) 2 μg/mL.

Gene/Protein Information For SIRT3 (Source: Uniprot.org, NCBI)

Alternative Names

EC 3.5.1; EC 3.5.1.-; hSIRT3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; NAD-dependent deacetylase sirtuin-3, mitochondrial; SIR2L3; SIR2L3silent mating type information regulation 2, S.cerevisiae, homolog 3; sir2-like 3; SIR2-like protein 3; SIRT3; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 3; Sirtuin 3; sirtuin type 3 SIRT3 SIR2L3 sirtuin 3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial|NAD-dependent deacetylase sirtuin-3, mitochondrial|SIR2-like protein 3|mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase|regulatory protein SIR2 homolog 3|silent mating type information regulation 2, S.cerevisiae, homolog 3|sir2-like 3|sirtuin type 3

For more info on SIRT3, check out the SIRT3 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for SIRT3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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