SPTBN2 Antibodies

AND SPTBN2 ELISA kits, SPTBN2 Proteins

Many biological assays use antibodies to detect SPTBN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPTBN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPTBN2 antibodies...

We validate the specificity of these antibodies to SPTBN2 by testing them on tissues known to express SPTBN2 positively and negatively. Browse below to find the SPTBN2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for SPTBN2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the SPTBN2 IHC Guide

SPTBN2 Infographic by Boster Bio

All SPTBN2 Products

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Product

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Specificity

Applications

Price

Anti-SPTBN2 Antibody Picoband®

Western blot analysis of SPTBN2 using anti-SPTBN2 antibody (A05492)

IHC analysis of SPTBN2 using anti-SPTBN2 antibody (A05492)

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A05492
100 µg/vial

SPTBN2 (NM_006946) Human Over-expression Lysate

Human

$960
Cat # LS006712
20 µg, 100 µg

SPTBN2 Overview

Facts about Spectrin beta chain, non-erythrocytic 2.

SPTBN2 3D structure. Source: alphafold

Spectrin beta chain, non-erythrocytic 2 (SPTBN2)

Probably plays an important role in neuronal membrane skeleton. .

Gene Information

Human
Gene Name:	SPTBN2
Uniprot:	O15020
Entrez:	6712

Family

Belongs to:

spectrin family

Alternative Names

beta-III Spectrin; glutamate transporter EAAT4-associated protein 41; GTRAP41; KIAA0302; SCA5; SCAR14; Spectrin beta 3; spectrin beta chain, brain 2; Spectrin beta III; spectrin, beta, non-erythrocytic 2; Spectrin, non-erythroid beta chain 2; spinocerebellar ataxia 5; SPTBN2

Molecular Weight

Mass (kDA):
271.325 kDA

Genomic Context


Human

Location:	11q13.2
Sequence:	11; NC_000011.10 (66682496..66729361, complement)

Tissue Specificity

Highly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta.

Subcellular Localizations

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.

Diseases

Ataxia, Spinocerebellar
Ataxia
Cerebellar Ataxia
Neurodegenerative Disorders
Spinocerebellar Ataxia Type 5
Atrophy
Cerebellar Diseases
Spinocerebellar Ataxia 20
Dysarthria
Nerve Degeneration
Friedreich Ataxia
Polyneuropathy

Respiration Disorders
Nystagmus
Spastic Ataxia, Charlevoix-saguenay Type
Oculomotor Apraxia
Pituitary Diseases
Asthma

Pathways

Transport
Lens Fiber Cell Differentiation
Intracellular Transport
Cell Proliferation
Cell Development
Brain Development
Cell Differentiation
Synaptic Transmission

Cognition
Pathogenesis
Cell Maturation

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPTBN2

References

PMID: 9826670 by Stankewich M.C., et al. A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles.

PMID: 23236289 by Lise S., et al. Recessive mutations in SPTBN2 implicate beta-III spectrin in both cognitive and motor development.