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- Table of Contents
ABCB6 Antibodies
AND ABCB6 ELISA kits, ABCB6 Proteins
Many biological assays use antibodies to detect ABCB6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCB6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCB6 antibodies...
Designing an IHC experiment for ABCB6? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the ABCB6 IHC GuideABCB6 Infographic by Boster Bio
All ABCB6 Products
Product
Figures
Specificity
Applications
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ABCB6 Overview
Facts about ATP-binding cassette sub-family B member 6, mitochondrial.
ATP-binding cassette sub-family B member 6, mitochondrial (ABCB6)
Binds heme and porphyrins and functions within their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.
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Gene Information
| Human | |
|---|---|
| Gene Name: | ABCB6 |
| Uniprot: | Q9NP58 |
| Entrez: | 10058 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ABC; ABC14; ABCB6; ATP-binding cassette, sub-family B (MDR/TAP), member 6; EC 3.6.3; EST45597; FLJ22414; LAN; MCOPCB7; Mitochondrial ABC transporter 3; mitochondrial; MTABC3; MTABC3ABC14; P-glycoprotein-related protein; PRP; Umat
Molecular Weight
Mass (kDA):
93.886 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q35 |
| Sequence: | 2; NC_000002.12 (219209772..219218958, complement) |
Tissue Specificity
Widely expressed. High expression is detected in the retinal epithelium.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. localized to the endosome-like compartment and dendrite tips.
Diseases
- Malignant Neoplasms
- Neoplasms
- Liver Carcinoma
- Carcinoma
- Prion Diseases
- Malignant Neoplasm Of Breast
- Anemia
- Liver Neoplasms
- Neoplasm Metastasis
- Mammary Neoplasms
- Malignant Neoplasm Of Liver
- Acute Erythroblastic Leukemia
- Leukemia
Pathways
- Transport
- Drug Resistance
- Localization
- Glycosylation
- Cell Cycle
- Cell Growth
- Gene Silencing
- Induction Of Apoptosis
- Electron Transport
- Electron Transport Chain
- Dna Repair
- Oxidative Phosphorylation
- Response To Oxidative Stress
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCB6
bosterbio.com/bosterbio-gene-info-cards/ABCB6
References
PMID: 10837493 by Mitsuhashi N., et al. MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis.
PMID: 11955620 by Emadi-Konjin H.-P., et al. Isolation of a genomic clone containing the promoter region of the human ATP binding cassette (ABC) transporter, ABCB6.
1 Publications of Boster ABCB6 Antibodies & ELISA Kits
- PubMed ID: 10.3390/cells10102549, New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NF-κB Signal...
*More publications can be found for each product on its corresponding product page