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- Table of Contents
ABCC1 Antibodies
AND ABCC1 ELISA kits, ABCC1 Proteins
Many biological assays use antibodies to detect ABCC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABCC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABCC1 antibodies...
Designing a Western blot for ABCC1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ABCC1 Western Blot GuideABCC1 Infographic by Boster Bio
All ABCC1 Products
Product
Figures
Specificity
Applications
Price
Anti-MRP1/ABCC1 Antibody Picoband®
11 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1634
100 μg/vial
Cat # PA1634
100 μg/vial
Anti-MRP1/ABCC1 Antibody Picoband®
7 Citations
Human
ELISA, Flow Cytometry, WB
$370
Cat # A00872-1
100 μg/vial
Cat # A00872-1
100 μg/vial
ABCC1 Overview
Facts about Multidrug resistance-associated protein 1.
Multidrug resistance-associated protein 1 (ABCC1)
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics.
Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficacy.
Gene Information
| Human | |
|---|---|
| Gene Name: | ABCC1 |
| Uniprot: | P33527 |
| Entrez: | 4363 |
Family
| Belongs to: |
|---|
| ABC transporter superfamily |
Alternative Names
ABC29; ABCC; ABCC1; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; EC 3.6.3; EC 3.6.3.44; GS-X; Leukotriene C(4) transporter; LTC4 transporter; MRP1; MRP1DKFZp781G125; MRPDKFZp686N04233; multidrug resistance associated protein 1; multidrug resistance protein; multidrug resistance-associated protein 1; multiple drug resistance protein 1; multiple drug resistance-associated protein
Molecular Weight
Mass (kDA):
171.591 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.11 |
| Sequence: | 16; NC_000016.10 (15949616..16143062) |
Tissue Specificity
Lung, testis and peripheral blood mononuclear cells.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Mammary Neoplasms
- Malignant Neoplasm Of Lung
- Leukemia
- Lung Neoplasms
- Ovarian Neoplasm
- Liver Neoplasms
- Malignant Paraganglionic Neoplasm
- Hiv Infections
- Liver Carcinoma
Pathways
- Transport
- Drug Resistance
- Localization
- Drug Transport
- Excretion
- Cell Proliferation
- Organic Anion Transport
- Anion Transport
- Cell Migration
- Cell Cycle
- Cell Growth
- Secretion
- Gene Silencing
PTMs
- Phosphorylation
- Carboxylation
- Cleavage
- Glycosylation
- Methylation
Research Areas
- ABC Transporters
- Amino Acids, Drugs and other small molecules
- Cancer
- Lipid and Metabolism
- Plasma Membrane Markers
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCC1
bosterbio.com/bosterbio-gene-info-cards/ABCC1
References
PMID: 1360704 by Cole S.P.C., et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.
PMID: 8098549 by Cole S.P.C., et al. Multidrug resistance-associated protein: sequence correction.
9 Publications of Boster ABCC1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/ijo.2016.3442, Cisplatin-induced CCL5 secretion from CAFs promotes cisplatin-resistance in ovar...
- PubMed ID: 10.1093/abbs/gmt062, Vascular endothelial growth factor induces multidrug resistance-associated prote...
- PubMed ID: 10.1016/j.leukres.2016.10.003, Differential expression and response to arsenic stress of MRPs and ASAN1 determi...
- PubMed ID: 29399180, Characteristics of doxorubicin-selected multidrug-resistant human leukemia HL-60...
- PubMed ID: 29217817, Acetazolamide Suppresses Multi-Drug Resistance-Related Protein 1 and P-Glycoprot...
- PubMed ID: 26767845, Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance ...
- PubMed ID: 26543365, Enhanced combination therapy effect on paclitaxel-resistant carcinoma by chloroq...
- PubMed ID: 23274417, Wang Y, Fang J, Huang S, Chen L, Fan G, Wang C. Environ Toxicol Pharmacol. 2013 ...
- PubMed ID: 24175763, Wang Nn, Zhao Lj, Wu Ln, He Mf, Qu Jw, Zhao Yb, Zhao Wz, Li Js, Wang Jh. Asian P...
*More publications can be found for each product on its corresponding product page