Multidrug resistance-associated protein 1 (ABCC1)

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics.

Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficacy.