Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 1(ABCC1) detection. Tested with WB, IHC-P in Human;Mouse;Rat. Cited in 6 publication(s).
Anti-MRP1/ABCC1 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-MRP1/ABCC1 Antibody
See all MRP1 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for MRP1/ABCC1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. MRP1/ABCC1 information: Molecular Weight: 171591 MW; Subcellular Localization: Cell membrane ; Multi-pass membrane protein ; Tissue Specificity: Lung, testis and peripheral blood mononuclear cells.|
|Cite This Product||Anti-MRP1/ABCC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1634)|
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|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1(1514-1531aa, LLQQRGLFYSMAKDAGLV), different from the related rat and mouse sequences by one amino acid.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For ABCC1 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||4363|
|Species Of This Entry||Human|
|Protein Name||Multidrug resistance-associated protein 1|
|Superfamily||ABC transporter superfamily|
|Alternative Names||MRP1|ABC29; ABCC; ABCC1; ATP-binding cassette sub-family C member 1; ATP-binding cassette, sub-family C (CFTR/MRP), member 1; EC 3.6.3; EC 18.104.22.168; GS-X; Leukotriene C(4) transporter; LTC4 transporter; MRP1; MRP1DKFZp781G125; MRPDKFZp686N04233; multidrug resistance associated protein 1; multidrug resistance protein; multidrug resistance-associated protein 1; multiple drug resistance protein 1; multiple drug resistance-associated protein|
|Post Tranlational Modifications||Phosphorylation; Carboxylation; Cleavage; Glycosylation; Methylation; Dephosphorylation; Bromination; Biotinylation; Oxidation; Ubiquitination|
|Subcellular Localization||Cell membrane; Multi-pass membrane protein.|
|Gene Location||16p13.11, on Chromasome 16, gene sequence: NC_000016.10 (15949616..16143062)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For ABCC1 (Source: Uniprot.org, NCBI)
|Protein Function||Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.|
|Tissue Specificity||Lung, testis and peripheral blood mononuclear cells.|
|Research Areas||ABC Transporters; Amino Acids, Drugs and other small molecules; Cancer; Lipid and Metabolism; Plasma Membrane Markers; Signal Transduction|
|Related Diseases||Malignant Neoplasms; Neoplasms; Malignant Neoplasm Of Breast; Carcinoma; Mammary Neoplasms; Malignant Neoplasm Of Lung; Leukemia; Lung Neoplasms; Ovarian Neoplasm; Liver Neoplasms; Malignant Paraganglionic Neoplasm; Hiv Infections; Liver Carcinoma; Myeloid Leukemia; Malignant Neoplasm Of Ovary; Immunologic Deficiency Syndromes; Medication Reaction; Epithelial Ovarian Cancer; Adenocarcinoma; Non-small Cell Lung Carcinoma|
|Related Pathways||Transport; Drug Resistance; Localization; Drug Transport; Excretion; Cell Proliferation; Organic Anion Transport; Anion Transport; Cell Migration; Cell Cycle; Cell Growth; Secretion; Gene Silencing; Sensitization; Conjugation; Cell Death; Dna Repair; Immune Response; Sulfate Transport; Lipid Homeostasis|
|Background||Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.|
|Scientific References||PMID: 1360704 by Cole S.P.C., et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.|
PMID: 8098549 by Cole S.P.C., et al. Multidrug resistance-associated protein: sequence correction.
Our Boster Quality Guarantee for Anti-MRP1/ABCC1 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: JURKAT Cell Lysate
Lane 2: CEM Cell Lysate
Lane 3: A549 Cell Lysate
IHC(P): Human Lung Cancer Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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Total number of citations: 6
|Wang Nn, Zhao Lj, Wu Ln, He Mf, Qu Jw, Zhao Yb, Zhao Wz, Li Js, Wang Jh. Asian Pac J Cancer Prev. 2013;14(9):4983-8. Mechanistic Analysis Of Taxol-Induced Multidrug Resistance In An Ovarian Cancer Cell Line.||PubMed ID 24175763|
|Wang Y, Fang J, Huang S, Chen L, Fan G, Wang C. Environ Toxicol Pharmacol. 2013 Jan;35(1):109-16. Doi: 10.1016/J.Etap.2012.12.001. Epub 2012 Dec 10. The Chronic Effects Of Low Lead Level On The Expressions Of Nrf2 And Mrp1 Of The Testes In The Rats.||PubMed ID 23274417|
|Enhanced combination therapy effect on paclitaxel-resistant carcinoma by chloroquine co-delivery via liposomes||PubMed ID 26543365|
|Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple negative breast cancer cells||PubMed ID 26767845|
|Acetazolamide Suppresses Multi-Drug Resistance-Related Protein 1 and P-Glycoprotein Expression by Inhibiting Aquaporins Expression in a Mesial Temporal Epilepsy Rat Model||PubMed ID 29217817|
|Characteristics of doxorubicin-selected multidrug-resistant human leukemia HL-60 cells with tolerance to arsenic trioxide and contribution of leukemia stem cells||PubMed ID 29399180|
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Note: sample size takes longer to process, average 5-7 days.
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