ABCE1 Antibodies

ATP-binding cassette sub-family E member 1 (ABCE1)

Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and so inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover.

Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.

Gene Information

Human
Gene Name:	ABCE1
Uniprot:	P61221
Entrez:	6059

Family

Belongs to:
ABC transporter superfamily

Alternative Names

2'-5'-oligoadenylate-binding protein; ATP-binding cassette, sub-family E (OABP), member 1; huHP68; OABP; Ribonuclease 4 inhibitor; ribonuclease L (2'-5'-oligoisoadenylate synthetase-dependent) inhibitor; RLIABC38; RNase L inhibitor; RNASEL1; RNASELIRNS4IATP-binding cassette sub-family E member 1

Molecular Weight

Mass (kDA):
67.314 kDA

Genomic Context

Human
Location:	4q31.21
Sequence:	4; NC_000004.12 (145098311..145129524)

Subcellular Localizations

Cytoplasm. Mitochondrion. Localized to clusters of virus formation at the plasma membrane.

Diseases

• Malignant Neoplasms
• Hiv Infections
• Neoplasms
• Virus Diseases
• Carcinoma
• Immunologic Deficiency Syndromes
• Lung Neoplasms
• Neoplasm Metastasis
• Adenocarcinoma
• Chronic Fatigue Syndrome
• Liver Carcinoma
• Prostatic Neoplasms

• Liver Neoplasms
• Adenocarcinoma Of Lung (disorder)
• Malignant Neoplasm Of Lung
• Infective Disorder
• Malignant Neoplasm Of Prostate
• Autoimmunity
• Intraepithelial Neoplasia

Pathways

• Translation
• Cell Growth
• Transport
• Pathogenesis
• Localization
• Rna Interference
• Muscle Cell Differentiation
• Gene Silencing
• Virulence
• Tropism
• Cell Division
• Cell Differentiation
• Myoblast Differentiation

• Cell Proliferation
• Induction Of Apoptosis
• Virus Maturation
• Dna Repair
• Cellular Process
• Methylation
• Drug Resistance

PTMs

• Phosphorylation

• Cleavage

• Methylation

Research Areas

• ABC Transporters
• Immune System Diseases
• Immunology
• Lipid and Metabolism
• Membrane Trafficking and Chaperones

• Plasma Membrane Markers
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABCE1

Best Uses Of The ABCE1 Marker

There are many biological assays that utilize antibodies to detect Putative protein BCE-1. These antibodies react with Putative proteins BCE-1 in a variety animal samples. They can be monoclonal (or polyclonal) Boster Bio created Putative protein BCE1 antibody against rabbit and mouse. Continue reading to learn more about these antibodies. Find out more information about Steven Boster and his history.

Histology

ABCE1 protein expression was associated with breast cancer recurrences early and poor prognosis. It is a potential biomarker for EAC, as it regulates prostaglandin E2-related pathways. It may also be a therapeutic target. Its role in cancer biology is still unclear. Further studies are required to confirm this. To confirm its role in the disease, further research is needed to determine its exact expression levels.

Numerous studies have examined ABCB1 genes. Among these studies are Okuno et al. 's findings from a study involving 116 patients affected by ESCC. Narumiya and colleagues also conducted another study. The ABCB1 marker was examined in 51 Japanese patients with unspecified histology. It was found that the CC genotype was associated more with ESCC risk, but less with the risk of large tumors.

Many factors affect the activity ABC transporters. Somatic and germline genetic aberrations alter gene transcription and protein stability. Epigenetic changes alter gene expression and splicing, leading to aberrant protein stability. Genetic background and epigenetics play a role in ABC transporter activity. These processes have been implicated as a factor in the development and progression of many diseases, including breast cancer. However, further research is needed to determine the exact role of ABCE1 for human cancer.

ABCE1 expression increases in chemoresistant patients. This could be a biomarker of treatment response. This resistance might be inbuilt in chemotherapy naive cells or acquired from repeated treatments. Although the reasons for resistance are still not fully understood, it is possible to identify the best treatment regimen. This research could lead also to the discovery or modification of therapeutic targets. The authors' review of ABC transporter expression in the human tumor cell phenotype was presented, which should lead to a better understanding of how ABCA resistance impacts the cancer cells.

Gene Infographics

In this article, we'll be discussing three types of gene informationgraphics based the ABCE1 or ABCE1 markers. These are COMPARTMENTS-based Curated Protein Location Evidence Scores. These score identify cellular components that contain the ABCE1 protein. Gene infographics based on this marker will also highlight the most prevalent variants of ABCE1.

The ABCE1 gene is expressed in high numbers in the nucleus cells, which is the primary target for HIV. The ABCE1 gene is found in the nucleus of the human eukaryotic cell. The ABCE1 protein is expressed in nearly half of human cells. It has been linked to many diseases, including Alzheimer's disease and cancer. Its expression levels may play a role for disease progression.

Histological Background

Histological studies are performed to understand the pathology of various disease processes. This science uses many techniques to microscopically examine tissues and cells. The field is used extensively in medicine and diagnosis. The field's findings are valuable in helping to treat diseases. The methods used in the study of tissues include X-ray fluorescence microscopy, cytology, and immunohistochemistry.

Histology's history shows that many techniques have evolved over time, including chemical staining, immunological protocols, and molecular biology. Early histologists used readily accessible chemicals such as alcohol and mercuric chloride, silver nitrate, and Giemsa stain. Modern techniques have led to the discovery of new and innovative methods for histological staining.