ABHD5 Antibodies

AND ABHD5 ELISA kits, ABHD5 Proteins

Many biological assays use antibodies to detect ABHD5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ABHD5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ABHD5 antibodies...

We validate the specificity of these antibodies to ABHD5 by testing them on tissues known to express ABHD5 positively and negatively. Browse below to find the ABHD5 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ABHD5 Infographic by Boster Bio

All ABHD5 Products

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Specificity

Applications

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Anti-Abhd5 Antibody Picoband®

1 Q&As

Western blot analysis of Abhd5 using anti-Abhd5 antibody (PB10021)

IHC analysis of Abhd5 using anti-Abhd5 antibody (PB10021)

IF analysis of Abhd5 using anti-Abhd5 antibody (PB10021)

Human, Rat

IF, IHC, ICC, WB

$370
Cat # PB10021
100 μg/vial

Anti-ABHD5 Monoclonal Antibody

5 Q&As

Western blot analysis of ABHD5 expression in HepG2 cell lysate

Human

Flow Cytometry, IHC, WB

$370
Cat # M03209
100 μl

ABHD5 (NM_016006) Human Over-expression Lysate

Human

$628
Cat # LS051099
20 µg, 100 µg

ABHD5 Overview

Facts about 1-acylglycerol-3-phosphate O-acyltransferase ABHD5.

ABHD5 3D structure. Source: alphafold

1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5)

Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289).

Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity).

Gene Information

Human
Gene Name:	ABHD5
Uniprot:	Q8WTS1
Entrez:	51099

Family

Belongs to:

peptidase S33 family

Alternative Names

abhydrolase domain containing 5; Abhydrolase domain-containing protein 5,1-acylglycerol-3-phosphate O-acyltransferase ABHD5; CDS; CGI58; EC 2.3.1.51; IECN2; Lipid droplet-binding protein CGI-58; MGC8731; NCIE2CGI-58

Molecular Weight

Mass (kDA):
39.096 kDA

Genomic Context


Human

Location:	3p21.33
Sequence:	3; NC_000003.12 (43690870..43734371)

Tissue Specificity

Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level).

Subcellular Localizations

Cytoplasm. Lipid droplet. Cytoplasm, cytosol. Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA (By similarity).

Diseases

Triglyceride Storage Disease With Ichthyosis
Ichthyoses
Lipoidosis
Storage Disease
Myopathy
Fatty Liver
Ichthyosiform Erythroderma, Congenital
Steatohepatitis
Obesity
Congenital Nonbullous Ichthyosiform Erythroderma
Exfoliative Dermatitis
Steatosis
Liver Diseases

Insulin Resistance
Metabolic Diseases
Hepatomegaly
Liver Cirrhosis
Congenital Ichthyosis
Hereditary Diseases
Lipid Metabolism Disorders

Pathways

Lipid Storage
Pathogenesis
Localization
Secretion
Lipid Homeostasis
Fatty Acid Oxidation
Rna Interference
Transport
Keratinization
Keratinocyte Differentiation
Energy Homeostasis

Nuclear Export
Methylation
Translation
Lipid Binding
Lipid Transport

PTMs

Phosphorylation
Acylation

Oxidation
Nitration

Methylation

Research Areas

Lipid and Metabolism
Lipid Droplets

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ABHD5

References

PMID: 11590543 by Lefevre C., et al. Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome.

PMID: 16679289 by Lass A., et al. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome.