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- Table of Contents
Facts about Alkaline ceramidase 1.
Has an extremely restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, in addition to complex sphingolipids (By similarity).
Human | |
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Gene Name: | ACER1 |
Uniprot: | Q8TDN7 |
Entrez: | 125981 |
Belongs to: |
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alkaline ceramidase family |
Acylsphingosine deacylase 3; Alkaline CDase 1; alkaline ceramidase 1; AlkCDase 1; ALKCDase1; ASAH3; EC 3.5.1.23; MGC138327; MGC138329; N-acylsphingosine amidohydrolase (alkaline ceramidase) 3; N-acylsphingosine amidohydrolase 3
Mass (kDA):
31.095 kDA
Human | |
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Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (6306142..6360368, complement) |
Mainly expressed in epidermis.
Endoplasmic reticulum membrane; Multi-pass membrane protein.
PMID: 12783875 by Mao C., et al. Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides.
PMID: 16477081 by Houben E., et al. Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis.