ACSL1 Antibodies

AND ACSL1 ELISA kits, ACSL1 Proteins

Many biological assays use antibodies to detect ACSL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ACSL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ACSL1 antibodies...

We validate the specificity of these antibodies to ACSL1 by testing them on tissues known to express ACSL1 positively and negatively. Browse below to find the ACSL1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for ACSL1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the ACSL1 Western Blot Guide

ACSL1 Infographic by Boster Bio

All ACSL1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-ACSL1 Antibody Picoband®

IHC analysis of ACSL1 using anti-ACSL1 antibody (PB10025)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB10025
100 μg/vial

ACSL1 (NM_001995) Human Over-expression Lysate

Human

$628
Cat # LS002180
20 µg, 100 µg

ACSL1 Overview

Facts about Long-chain-fatty-acid--CoA ligase 1.

ACSL1 3D structure. Source: alphafold

Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.

Gene Information

Human
Gene Name:	ACSL1
Uniprot:	P33121
Entrez:	2180

Family

Belongs to:

ATP-dependent AMP-binding enzyme family

Alternative Names

ACS1LACS 2; Acyl-CoA synthetase 1; acyl-CoA synthetase long-chain family member 1; EC 6.2.1; FACL1EC 6.2.1.3; fatty-acid-Coenzyme A ligase, long-chain 1; LACS 1; LACSlong-chain 2; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 1; Long-chain acyl-CoA synthetase 2; Long-chain fatty acid-CoA ligase 2; long-chain fatty-acid-coenzyme A ligase 1; long-chain-fatty-acid--CoA ligase 1; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2; paltimoyl-CoA ligase 1

Molecular Weight

Mass (kDA):
77.943 kDA

Genomic Context


Human

Location:	4q35.1
Sequence:	4; NC_000004.12 (184755595..184826593, complement)

Tissue Specificity

Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.

Subcellular Localizations

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Diseases

Obesity
Insulin Resistance
Diabetes Mellitus
Fatty Liver
Insulin Sensitivity
Liver Carcinoma
Steatohepatitis
Steatosis
Liver Neoplasms
Liver Diseases
Cardiac Hypertrophy
Fibrosis
Hepatitis

Hyperinsulinism
Physiological Stress
Diabetes Mellitus, Experimental
Hypertrophy
Diabetes Mellitus, Insulin-dependent
Inflammation
Nonalcoholic Fatty Liver Disease

Pathways

Transport
Fatty Acid Transport
Parturition
Localization
Fatty Acid Oxidation
Secretion
Glucose Homeostasis
Lactation
Cell Fate Determination
Hepatocyte Proliferation
Embryo Development
Regulation Of Hepatocyte Proliferation
Cholesterol Efflux

Response To Cold
Transdifferentiation
Cell Proliferation
Mitosis
Dna Methylation
Protein Transport
Macrophage Activation

PTMs

Oxidation
Phosphorylation
Acylation

Reduction
Acetylation
Methylation

Research Areas

Cancer
Lipid and Metabolism
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACSL1

References

PMID: 1607358 by Abe T., et al. Human long-chain acyl-CoA synthetase: structure and chromosomal location.

PMID: 8584017 by Ghosh B., et al. Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression.